{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐223 functions as a key regulator of innate immunity and inflammatory homeostasis. It directly suppresses NLRP3 inflammasome expression in myeloid cells, thereby dampening IL‐1β production and neutrophil recruitment in diseases such as tuberculosis and inflammatory bowel disease. In addition, miR‐223 is packaged into microvesicles and exosomes—being secreted by macrophages and platelets—and transferred to neighboring cells to modulate endothelial activation, adhesion molecule expression, and even allograft inflammation. These intercellular communication mechanisms are central to its role as an “inflammatory rheostat” that prevents excessive immune activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer and hematopoiesis, miR‐223 exhibits diverse and sometimes contrasting roles. In acute myeloid leukemia, its downregulation—whether via epigenetic silencing by oncogenic fusion proteins or through repression by cell cycle regulators like E2F1—contributes to a block in granulocytic differentiation, while restoration of its levels facilitates normal myelopoiesis. In T‐cell leukemias, oncogenic transcription factors (such as TAL1) trigger miR‐223 upregulation leading to repression of tumor suppressors like FBXW7. Moreover, in several solid tumors—including gastric, hepatocellular, ovarian, and colorectal cancers—deregulated miR‐223 influences tumor cell migration, invasion, and chemoresistance by targeting genes such as EPB41L3, FOXO1, and the drug efflux mediator ABCB1; its altered circulating levels further point to its potential utility as a non‐invasive biomarker for liver injury and cancer prognosis. Collectively, these data underscore miR‐223’s role as both a mediator of differentiation and a modulator of oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nmiR‐223 also contributes to metabolic and vascular regulation. 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