HGNC Family | Non-coding RNAs |
Name | MIR22 host gene |
Description | Predicted to act upstream of or within response to wounding. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
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These findings underscore its potential as both a diagnostic/prognostic biomarker and a therapeutic target in cancer treatment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, MIR22HG plays critical roles in normal physiological and stress‐related processes. In human-induced pluripotent stem cells, MIR22HG is among a set of long noncoding RNAs that respond rapidly and robustly to chemical stresses, suggesting its involvement in broader cellular stress responses. Additionally, in bone biology, MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis models while its modulation in human adipose-derived stem cells influences chondrogenic differentiation through interactions with transcriptional regulators like CTCF and subsequent regulation of factors such as CRLF1. Moreover, in adenomyosis, MIR22HG is implicated together with specific microRNAs in controlling endometrial cell proliferation; and emerging data in nonalcoholic steatohepatitis indicate its potential association with autophagy, pyroptosis, and fibrosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPan‐cancer analyses further highlight the complexity and broad clinical relevance of MIR22HG. Its dysregulation across multiple tumor types—including colorectal cancer where lncRNA expression patterns warrant further investigation—and in immune‐related contexts underscores the diverse regulatory networks in which MIR22HG participates. In population‐based studies and integrated bioinformatics analyses, MIR22HG expression is being evaluated as a prognostic biomarker with potential to guide therapeutic strategies. Additionally, related studies examining circulating microRNAs in autoimmune conditions point to the broader significance of the MIR22 locus and its regulatory network, reinforcing the notion that noncoding RNAs are key players in human disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenmei Su, Shumei Feng, Xiuyuan Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02813-2"}], "href": "https://doi.org/10.1038/s41419-020-02813-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32732881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32732881"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ke Yu, Shuna Cui, Tongmin Xue "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR22HG is downregulated in adenomyosis and upregulates miR-2861 through demethylation to inhibit endometrial cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.14665"}], "href": "https://doi.org/10.1111/jog.14665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33624428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33624428"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jiajia Guo, Wang Ye, Xinglin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-023-01248-0"}], "href": "https://doi.org/10.1007/s10142-023-01248-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37910254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37910254"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xuanxin Chen, Shibo Zhou, Yiyu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Nutr (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clnu.2023.11.004"}], "href": "https://doi.org/10.1016/j.clnu.2023.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38011754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38011754"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Juan Xu, Tingting Shao, Mingxu Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-020-01174-w"}], "href": "https://doi.org/10.1186/s12943-020-01174-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32127004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32127004"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jifeng Tang, Junyu Lin, Ziqing Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Rheumatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.55563/clinexprheumatol/4me6tg"}], "href": "https://doi.org/10.55563/clinexprheumatol/4me6tg"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33635234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33635234"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "H Wang, W Li, D Zhang "}, {"type": "b", "children": [{"type": "t", "text": "[Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2022.04.03"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2022.04.03"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35527483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35527483"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zhao-Ru Dong, Jia-Bin Cai, Guo-Ming Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2023.216186"}], "href": "https://doi.org/10.1016/j.canlet.2023.216186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37105392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37105392"}]}]}]}
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Synonyms | C17ORF91 |
Proteins | CQ091_HUMAN |
NCBI Gene ID | 84981 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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MIR22HG has 6,559 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 42 datasets.
Click the + buttons to view associations for MIR22HG from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MIR22HG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MIR22HG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of MIR22HG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MIR22HG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR22HG gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MIR22HG gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR22HG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR22HG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with MIR22HG gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR22HG gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR22HG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIR22HG gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR22HG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with MIR22HG gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with MIR22HG gene/protein from the curated CTD Gene-Disease Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR22HG gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR22HG gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR22HG gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MIR22HG from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MIR22HG from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MIR22HG gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIR22HG gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR22HG gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MIR22HG gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR22HG gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MIR22HG gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of MIR22HG gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with MIR22HG gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with MIR22HG gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR22HG gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR22HG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR22HG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of MIR22HG gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of MIR22HG gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIR22HG gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MIR22HG protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting MIR22HG gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR22HG gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MIR22HG gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MIR22HG gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR22HG gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MIR22HG gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |