{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR22HG is emerging as a multifunctional long noncoding RNA with prominent tumor‐suppressive roles in a variety of cancers. In lung cancer, hepatocellular carcinoma, endometrial cancer, esophageal adenocarcinoma, thyroid cancer, laryngocarcinoma, prostate cancer, bladder cancer, and small cell lung cancer, reduced MIR22HG expression is frequently associated with aggressive tumor features and poor patient outcomes. Mechanistic studies reveal that MIR22HG exerts its antitumor effects by binding and stabilizing critical proteins (e.g., YBX1), acting as a competing endogenous RNA (ceRNA) that sponges oncogenic microRNAs (such as miR‐10a‐5p, miR‐141‐3p, miR‐5000‐3p, miR‐629-5p), and thereby modulating key signaling pathways including Wnt/β‐catenin, Hippo, AKT and others. These findings underscore its potential as both a diagnostic/prognostic biomarker and a therapeutic target in cancer treatment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, MIR22HG plays critical roles in normal physiological and stress‐related processes. In human-induced pluripotent stem cells, MIR22HG is among a set of long noncoding RNAs that respond rapidly and robustly to chemical stresses, suggesting its involvement in broader cellular stress responses. Additionally, in bone biology, MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis models while its modulation in human adipose-derived stem cells influences chondrogenic differentiation through interactions with transcriptional regulators like CTCF and subsequent regulation of factors such as CRLF1. Moreover, in adenomyosis, MIR22HG is implicated together with specific microRNAs in controlling endometrial cell proliferation; and emerging data in nonalcoholic steatohepatitis indicate its potential association with autophagy, pyroptosis, and fibrosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPan‐cancer analyses further highlight the complexity and broad clinical relevance of MIR22HG. Its dysregulation across multiple tumor types—including colorectal cancer where lncRNA expression patterns warrant further investigation—and in immune‐related contexts underscores the diverse regulatory networks in which MIR22HG participates. In population‐based studies and integrated bioinformatics analyses, MIR22HG expression is being evaluated as a prognostic biomarker with potential to guide therapeutic strategies. Additionally, related studies examining circulating microRNAs in autoimmune conditions point to the broader significance of the MIR22 locus and its regulatory network, reinforcing the notion that noncoding RNAs are key players in human disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenmei Su, Shumei Feng, Xiuyuan Chen, et al. 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