{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-2392 has emerged as an important regulator in cancer progression. In gastric cancer, it is down-regulated in tumor tissues and cell lines, and its overexpression significantly suppresses invasion and metastasis via direct targeting of oncogenic mediators such as MAML3 and WHSC1, thereby inhibiting epithelial‐mesenchymal transition and correlating with better patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study on hepatocellular carcinoma, the lncRNA CACNA1G‑AS1 was found to promote tumor progression by sponging miR-2392, which normally represses the expression of C1orf61, suggesting that disruption of the miR-2392/C1orf61 axis contributes to HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these oncologic settings, miR-2392 is also implicated in fibrotic processes. In human skin keloid fibroblasts, the application of botulinum toxin A was shown to upregulate miR-2392; this upregulation leads to the downregulation of ZEB2, a target whose suppression is associated with reduced cell proliferation and migration as well as enhanced apoptosis and autophagy, thereby suggesting a potential therapeutic role for miR-2392 modulation in keloids."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, miR-2392 plays a critical role in the host response during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Circulating miR-2392 is directly involved with the viral machinery during host infection by driving the downstream suppression of mitochondrial genes and promoting inflammation, glycolysis, and hypoxia—key features of COVID-19 symptomatology. Its unique presence in the blood and urine of COVID-19 positive patients further underscores its potential both as a biomarker for minimally invasive viral detection and as a target for miRNA-based antiviral intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinjing Li, Tingyu Li, Yuanyuan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-2392 suppresses metastasis and epithelial-mesenchymal transition by targeting "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MAML3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "WHSC1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201601140RR"}], "href": "https://doi.org/10.1096/fj.201601140RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28512191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28512191"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinghui Yang, Chunsheng Li, Hang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression through the miR-2392/C1orf61 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28477"}], "href": "https://doi.org/10.1002/jcp.28477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30908634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30908634"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhanying Hou, Feixiang Fan, Po Liu "}, {"type": "b", "children": [{"type": "t", "text": "BTXA regulates the epithelial-mesenchymal transition and autophagy of keloid fibroblasts via modulating miR-1587/miR-2392 targeted ZEB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190679"}], "href": "https://doi.org/10.1042/BSR20190679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31652445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31652445"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J Tyson McDonald, Francisco J Enguita, Deanne Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of miR-2392 in driving SARS-CoV-2 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.109839"}], "href": "https://doi.org/10.1016/j.celrep.2021.109839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34624208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34624208"}]}]}]}