{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in hepatocellular carcinoma (HCC) have demonstrated that miR‑23c functions as a tumor suppressor whose reduced expression in HCC tissues and cell lines is associated with larger tumor sizes, higher tumor grades, advanced TNM stages, and poorer patient survival. Experimental overexpression of miR‑23c inhibited cell proliferation and induced apoptosis in vitro, and it also repressed tumor growth in vivo. Mechanistically, miR‑23c directly targets the 3′‑UTR of erbb2 interacting protein (ERBB2IP), thereby suppressing its expression. In this way, the down‐regulation of ERBB2IP by miR‑23c contributes to the attenuation of oncogenic signaling pathways that drive HCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, independent research has revealed that long non‑coding RNAs can modulate the levels and activity of miR‑23c through a ceRNA mechanism. Specifically, KTN1 antisense RNA 1 (KTN1‑AS1) has been shown to function as a molecular sponge for miR‑23c in HCC cells. This interaction sequesters miR‑23c and consequently leads to the derepression of ERBB2IP, thereby promoting cell proliferation. The interplay between KTN1‑AS1 and miR‑23c highlights a regulatory axis with potential diagnostic and therapeutic implications in the management of HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Zhang, Yufeng Wang, Liang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.07.155"}], "href": "https://doi.org/10.1016/j.biopha.2018.07.155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30103114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30103114"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lei Zhang, Liang Wang, Yufeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.10.105"}], "href": "https://doi.org/10.1016/j.biopha.2018.10.105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30551364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30551364"}]}]}]}