{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies at the MIR137/MIR2682 locus have revealed that genetic variation affecting noncoding enhancer regions can lead to reduced expression of both MIR137 and MIR2682. In one study focusing on schizophrenia and bipolar disorder, a rare enhancer single-nucleotide polymorphism (SNP) was found to significantly lower enhancer activity—by more than 50%—thereby predicting decreased expression of the MIR137/MIR2682 cluster. This reduction, likely mediated by altered binding of the transcription factor YY1, suggests that MIR2682, along with its partner MIR137, may play an important role in neuronal function and in the genetic susceptibility to these neuropsychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother study investigating head and neck squamous cell carcinoma examined the entire MIR137/MIR2682 locus, noting that a large CpG island encompassing most of the MIR137 gene extends downstream to just before MIR2682. This observation implies that epigenetic alterations at this shared genomic region could influence the expression of MIR2682 alongside MIR137, potentially impacting tumor suppressor functions in cancer. Although the specific biological role of MIR2682 in this context remains to be fully elucidated, its proximity to critical regulatory elements highlights its possible contribution to the gene regulatory network in head and neck cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jubao Duan, Jianxin Shi, Alessia Fiorentino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2014.11.001"}], "href": "https://doi.org/10.1016/j.ajhg.2014.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25434007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25434007"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Helena Čelešnik, Tomaž Büdefeld, Bogdan Čizmarević, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR137/MIR2682 locus is associated with perineural invasiveness in head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jop.13174"}], "href": "https://doi.org/10.1111/jop.13174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33740841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33740841"}]}]}]}