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Moreover, oncogenic drivers (e.g., MYC) and disruptions in miRNA maturation contribute to its dysregulation, thereby modulating chemoresistance and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in oncogenesis, MIR26A1 influences several non‑neoplastic processes. miR‑26a modulates key inflammatory and metabolic pathways by regulating cytokine production (including interleukin‑6 and interferon‑β), controlling TGF‑β/SMAD signaling, and fine‑tuning NF‑κB activity. These actions affect endothelial function, vascular smooth muscle cell proliferation and differentiation, angiogenesis, and wound healing. 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