MIR27B Gene

HGNC Family Non-coding RNAs
Name microRNA 27b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐27b (miR‐27b) has emerged as a key regulator in metabolic processes. In stem cells committed to the adipocyte lineage, miR‐27b is down‐regulated during adipogenesis and, when overexpressed, it represses master adipogenic regulators such as peroxisome proliferator‐activated receptor γ (PPARγ) through direct targeting—as evidenced in human adipose‐derived stem cells—and impairs mitochondrial function by reducing prohibitin expression. In parallel, miR‐27b has been identified as a central hub in liver lipid homeostasis where its hepatic levels respond to hyperlipidemia, and its dysregulation is associated with metabolic disorders including obesity, diabetes, and polycystic ovary syndrome. Moreover, during inflammatory challenges in macrophages, lipopolysaccharide‐induced miR‐27b destabilizes PPARγ1 mRNA, thereby modulating the expression of pro‐inflammatory cytokines."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn the vascular context, miR‐27b modulates angiogenic processes through multiple cell types. In endothelial cells, elevated miR‐27b promotes capillary sprouting by directly repressing the angiogenesis inhibitor semaphorin 6A. Its activity extends to the regulation of bone marrow–derived angiogenic cells, where miR‐27b has been shown to rescue impaired neovascular function in diabetes. Additionally, lower circulating levels of miR‐27b correlate with more severe diabetic retinopathy, and in aggressive ovarian cancer cells, miR‐27b inhibits vasculogenic mimicry by down‐regulating VE‐cadherin, thereby limiting the formation of tumor‐associated vascular networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond metabolism and vascular regulation, miR‐27b plays context‐dependent and sometimes opposing roles in cancer. In several malignancies, including glioma, breast, colorectal, prostate, bladder, non‐small cell lung, and clear cell renal cell carcinomas, aberrant miR‐27b expression—either up‐ or down‐regulation—has been linked to altered cell proliferation, invasion, metastasis, and chemoresistance. For example, in breast cancer, elevated miR‐27b promotes tumor growth by targeting tumor suppressors such as Nischarin, whereas in neuroblastoma and colorectal cancer, restoration of miR‐27b levels down‐regulates oncogenic mediators (e.g. PPARγ and vascular endothelial growth factor C) to inhibit tumor progression. In addition, miR‐27b modulates drug sensitivity by repressing targets involved in drug metabolism (such as dihydropyrimidine dehydrogenase) and by influencing key upstream regulators of intracellular signaling cascades—impacting tamoxifen resistance via HMGB3 as well as chemoresistance through CCNG1/p53‐dependent pathways. Its involvement also extends to the tumor microenvironment where, in esophageal and multiple myeloma contexts, miR‐27b contributes to fibroblast transformation and cancer stem cell maintenance by targeting factors like ENPP1, ultimately affecting metastatic potential and drug response. Collectively, these studies underscore the multifaceted functions of miR‐27b in cancer biology, acting as either an oncogene or tumor suppressor depending on the cellular context"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "32"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael Karbiener, Christoph Fischer, Susanne Nowitsch, et al. 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Synonyms MIR-27B, MIRNA27B, MIRN27B
NCBI Gene ID 407019
API
Download Associations
Predicted Functions View MIR27B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR27B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR27B's ARCHS4 Predicted Functions.

Functional Associations

MIR27B has 975 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 22 datasets.

Click the + buttons to view associations for MIR27B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR27B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR27B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR27B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with MIR27B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
CTD Gene-Disease Associations diseases associated with MIR27B gene/protein from the curated CTD Gene-Disease Associations dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with MIR27B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR27B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR27B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR27B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR27B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR27B from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR27B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR27B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of MIR27B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR27B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR27B gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR27B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR27B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR27B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR27B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with MIR27B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
WikiPathways Pathways 2014 pathways involving MIR27B protein from the Wikipathways Pathways 2014 dataset.