MIR2861 Gene

HGNC Family Non-coding RNAs
Name microRNA 2861
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of target mRNAs. This microRNA may play a role in osteoblast differentiation and a mutation in this gene is associated with osteoporosis. Altered expression of this microRNA has been observed in human cancers, with reduced expression seen in cervical cancer, while expression in papillary thyroid carcinoma (PTC) is increased. [provided by RefSeq, Mar 2017]
Summary
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These findings, together with evidence from scaffold‐assisted bone regeneration studies and investigations into mesenchymal stem cell differentiation, underscore the critical physiological function of MIR2861 in skeletal development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in osteogenesis, MIR2861 has emerged as a valuable biomarker in several clinical contexts. Its inclusion in a serum miRNA panel has improved the diagnosis of cervical cancer, and elevated levels have been correlated with lymph node metastasis in papillary thyroid carcinoma, suggesting a role in tumor progression. Moreover, increased circulating MIR2861 has been detected in the early stages of acute coronary syndrome. In lung cancer stem cells, MIR2861 contributes to the maintenance of stemness—likely via regulation of HDAC5 and modulation of ERK1/2 phosphorylation—further illustrating its diverse involvement in disease biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn reproductive pathologies, MIR2861 also exerts significant regulatory effects on cellular proliferation and apoptosis. It is downregulated in endometriotic tissues, a change that leads to the upregulation of molecules such as STAT3 and MMP2 and contributes to aberrant cell survival and proliferation. Similar alterations in MIR2861 expression have been implicated in adenomyosis, highlighting its potential as a diagnostic biomarker and therapeutic target in endometrial disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui Li, Hui Xie, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI39832"}], "href": "https://doi.org/10.1172/JCI39832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19920351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19920351"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "F Diomede, I Merciaro, S Martinotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-2861 is involved in osteogenic commitment of human periodontal ligament stem cells grown onto 3D scaffold."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28078846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28078846"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mingchang Du, Bo Wu, Shiwen Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG14 induces osteogenic differentiation of human stromal (mesenchymal) stem cells in vitro by downregulating miR-2861."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Musculoskelet Disord (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12891-020-03506-9"}], "href": "https://doi.org/10.1186/s12891-020-03506-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32770994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32770994"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yujuan Zhang, Donghong Zhang, Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep17942"}], "href": "https://doi.org/10.1038/srep17942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26656154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26656154"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhihong Wang, Hao Zhang, Ping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-2861 and miR-451 expression in papillary thyroid carcinoma with lymph node metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-013-0577-9"}], "href": "https://doi.org/10.1007/s12032-013-0577-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23609190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23609190"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiang-Dong Li, Yue-Jin Yang, Lai-Yuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated plasma miRNA-122, -140-3p, -720, -2861, and -3149 during early period of acute coronary syndrome are derived from peripheral blood mononuclear cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0184256"}], "href": "https://doi.org/10.1371/journal.pone.0184256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28961259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28961259"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mengya Zhao, Lin Li, Jundong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-2861 Behaves as a Biomarker of Lung Cancer Stem Cells and Regulates the HDAC5-ERK System Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Reprogram (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cell.2017.0045"}], "href": "https://doi.org/10.1089/cell.2017.0045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29620443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29620443"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hao Yu, Qun Zhong, Yali Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmazie (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1691/ph.2019.8881"}], "href": "https://doi.org/10.1691/ph.2019.8881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30940310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30940310"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ke Yu, Shuna Cui, Tongmin Xue "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR22HG is downregulated in adenomyosis and upregulates miR-2861 through demethylation to inhibit endometrial cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.14665"}], "href": "https://doi.org/10.1111/jog.14665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33624428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33624428"}]}]}]}
Synonyms BMND15, MIRN2861
NCBI Gene ID 100422910
API
Download Associations
Predicted Functions View MIR2861's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR2861's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR2861's ARCHS4 Predicted Functions.

Functional Associations

MIR2861 has 1,487 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR2861 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR2861 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR2861 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR2861 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CTD Gene-Disease Associations diseases associated with MIR2861 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR2861 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR2861 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR2861 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR2861 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR2861 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR2861 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR2861 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
OMIM Gene-Disease Associations phenotypes associated with MIR2861 gene from the curated OMIM Gene-Disease Associations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR2861 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.