{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-297 has emerged as a multifunctional regulator in cancer biology. In colorectal carcinoma, miR-297 is down-regulated in multidrug-resistant cells and contributes to chemoresistance via modulation of MRP-2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its precise role in lung cancer remains largely undefined"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", its overexpression in hepatocellular carcinoma has been shown to inhibit proliferation, migration, and invasion by targeting PTBP3 and dampening the PI3K/AKT pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in prostate cancer, when paired with miR-19b-3p, miR-297 serves as a diagnostic marker with high sensitivity and specificity, and is linked to the regulation of cell mobility via CFL2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, the potential of microRNAs as therapeutic tools in glioblastoma has been underscored, implicating miR-297 among other candidates to modulate dysregulated oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of inflammation and cellular injury, miR-297 plays pivotal but context-dependent roles. In lipopolysaccharide-induced human umbilical vein endothelial cells (HUVECs), miR-297 is involved in regulating inflammatory responses, potentially through cross-talk with STAT3 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In lung epithelial cells subjected to LPS challenge, overexpression of miR-297 alleviates cell apoptosis and inflammatory cytokine secretion by directly targeting CDK8 and subsequently inhibiting NF-κB pathway activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Conversely, in hypoxia/reoxygenation-induced hepatocyte injury, inhibition of miR-297 (via antagomir) protects cells by promoting SIRT3 expression and suppressing NLRP3 inflammasome activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer and inflammation, miR-297 is implicated in cardiovascular repair and reproductive function. In models of acute myocardial ischemia, a circular RNA (hsa_circ_0007623) acts as a molecular sponge for miR-297, thereby modulating VEGFA expression and enhancing endothelial cell proliferation, migration, and angiogenesis to promote cardiac repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, dysregulated miR-297 levels have been linked to progesterone resistance and impaired decidualization in endometrial stromal cells from women with endometriosis, suggesting a role in the modulation of endometrial receptivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ke Xu, Xin Liang, Ke Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20120386"}], "href": "https://doi.org/10.1042/BJ20120386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22676135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22676135"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yunchuan Sun, Jianyong Zhao, Xiaoming Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12288"}], "href": "https://doi.org/10.1111/cpr.12288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27554041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27554041"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Na Lu, Jiali Min, Lin Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-06097-0"}], "href": "https://doi.org/10.1038/s41419-023-06097-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37633911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37633911"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "A I Osip'yants, E N Knyazev, A V Galatenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-017-3620-6"}], "href": "https://doi.org/10.1007/s10517-017-3620-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28091918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28091918"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Benjamin Kefas, Desiree H Floyd, Laurey Comeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/not118"}], "href": "https://doi.org/10.1093/neuonc/not118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24158111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24158111"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yanfen Yao, Haiyan Jia, Geng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-297 Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Inflammatory Response and Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.33594/000000049"}], "href": "https://doi.org/10.33594/000000049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30921508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30921508"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xueqin Xi, Yanfen Yao, Na Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.106197"}], "href": "https://doi.org/10.1016/j.intimp.2020.106197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31945608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31945608"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuan Yue, Zhilin Du, Jie Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Physiol Pharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/cjpp-2021-0287"}], "href": "https://doi.org/10.1139/cjpp-2021-0287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34559973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34559973"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qian Zhang, Weixin Sun, Jie Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.12.116"}], "href": "https://doi.org/10.1016/j.bbrc.2019.12.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31973814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31973814"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tingting Liu, Li Xiao, Tianjiao Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-297 inhibits expression of progesterone receptor and decidualization in eutopic endometria of endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.15526"}], "href": "https://doi.org/10.1111/jog.15526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36572643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36572643"}]}]}]}