{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that MIR301B (and its closely related family members) functions as a potent oncogenic microRNA in several cancer types by modulating key tumor‐suppressive and signaling pathways. Early studies demonstrated that MIR301B, which is expressed from an intronic region and can regulate its host gene through a feedback mechanism via targeting factors such as MEOX2, impacts the ERK/CREB pathway and thereby modulates cell proliferation and mitosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic carcinoma, upregulation of MIR301B was shown to suppress tumor‐suppressor genes such as TP63, correlating with increased cell invasiveness and enhanced chemoresistance.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have extended the oncogenic role of MIR301B to other malignancies. In prostate cancer, its elevated expression (alongside related miR-301a) contributes to altered autophagy and cell viability by modulating targets like NDRG2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In lung cancer, MIR301B has been implicated in regulating apoptosis, whereas in mesenchymal stem cells, a miR-301b~miR-130b-PPARγ axis correlates with differential adipogenic capacity. Furthermore, MIR301B genetic variants are associated with increased breast cancer risk, and functional experiments in triple-negative breast cancer cells indicate that MIR301B promotes proliferation via targeting tumor suppressors such as CYLD."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": " In ovarian carcinoma, MIR301B enhances cell migration and invasion through a CPEB3/EGFR regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these contexts, MIR301B has been documented to drive tumorigenesis in hepatocellular carcinoma via repression of VGLL4, in gastric cancer through attenuation of ZBTB4, and in colorectal cancer by targeting HOXB1, while in breast cancer, it also suppresses HOXA5 expression leading to enhanced malignant behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": " Recent evidence further implicates MIR301B in non‐cancerous contexts; for example, within diabetic wound healing its activity is modulated by circular RNAs such as circARHGAP12, and in osteosarcoma, upregulated MIR301B promotes cellular malignancy by targeting SNX10. Comprehensive reviews confirm that aberrant expression of MIR301B is consistently associated with enhanced proliferation, migration, invasion, resistance to apoptosis, and poor clinical outcomes across diverse tumor types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guojun Cao, Baochun Huang, Zhaohui Liu, et al. 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