| HGNC Family | Non-coding RNAs |
| Name | microRNA 302a |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐302A, a key component of the miR‐302/367 cluster, is highly expressed in embryonic stem cells and induced pluripotent stem cells where it plays multifaceted roles in pluripotency and early cell fate decisions. Transcriptionally activated by core factors such as OCT4 and SOX2, miR‐302A enhances reprogramming efficiency by promoting rapid cell cycle progression through modulating the G1/S transition, suppressing inhibitors and targeting multiple regulators (including cyclin D1 and other epigenetic factors) to favor a stem‐like cell cycle profile. In addition, miR‐302A facilitates the mesenchymal–epithelial transition and delays differentiation by post‐transcriptionally repressing regulators such as the Nodal inhibitors and key epigenetic modifiers, thereby contributing to the maintenance of the pluripotent state and precise germ layer specification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse cancer contexts—including head and neck, cervical, glioblastoma, prostate, colorectal, ovarian, testicular germ cell, pancreatic and liver carcinomas—miR‐302A exerts context‐dependent regulatory functions that modulate cancer stemness, tumorigenicity and treatment response. By targeting key modulators such as AKT, cyclins, the TGFβ receptor, and transcription factors like IRF5, it can suppress oncogenic signaling pathways, reverse epithelial–mesenchymal transition and enhance cell cycle arrest. In several studies, ectopic or endogenous miR‐302A expression has been linked to the inhibition of cell proliferation, invasion, metastasis and chemoresistance, as well as to the promotion of ferroptotic or apoptotic cell death. Moreover, emerging evidence shows that miR‐302A can attenuate inflammatory cytokine storms during viral infections and may impact pathologic processes such as diabetic kidney disease, underscoring its broad therapeutic potential in both cancer and non‐malignant diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Deborah A Greer Card, Pratibha B Hebbar, Leping Li, et al. 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| Synonyms | MIRN302A, HSA-MIR-302, MIR-302A, MIRN302 |
| NCBI Gene ID | 407028 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR302A has 563 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.
Click the + buttons to view associations for MIR302A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR302A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR302A gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR302A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR302A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MIR302A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MIR302A from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MIR302A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIR302A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR302A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR302A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR302A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving MIR302A protein from the Reactome Pathways dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR302A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving MIR302A protein from the Wikipathways Pathways 2014 dataset. | |