MIR302C Gene

HGNC Family Non-coding RNAs
Name microRNA 302c
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In breast cancer, for example, miR‑302c was identified as one of five potent microRNAs that directly downregulate estrogen receptor‑α expression by targeting its 3′‑UTR, thereby contributing to the inhibition of estrogen‑stimulated cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn human embryonic stem cells, the miR‑302 family—including miR‑302c—plays a critical role in controlling the cell cycle by negatively regulating p21 expression, which helps maintain a noncanonical G1/S checkpoint before and after DNA damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in gastric cancer cells, alterations in the expression of miR‑302c are implicated in the regulation of tumor invasion: loss of the upstream regulator RACK1 leads to modulation of the IL8 expression via miR‑302c, forming a feedback loop that ultimately curbs tumor metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other oncogenic contexts, such as testicular germ cell tumors and lung adenocarcinoma, miR‑302c contributes to the regulation of critical signaling pathways. In testicular germ cell tumors, inhibition of miR‑302 family members—including miR‑302c—reduces SPRY4 expression and downstream MAPK/ERK signaling, thereby decreasing cell proliferation and survivin expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in lung adenocarcinoma, miR‑302c‑5p normally acts to suppress oncogenic signals by targeting factors such as FOXA1; its sequestration by long non‑coding RNAs like LINC00460 relieves this repression and promotes tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S-K Leivonen, R Mäkelä, P Ostling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.241"}], "href": "https://doi.org/10.1038/onc.2009.241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19684618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19684618"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dasa Dolezalova, Marek Mraz, Tomas Barta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.1108"}], "href": "https://doi.org/10.1002/stem.1108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22511267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22511267"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ling Chen, Lingqiang Min, Xuefei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-3690"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-3690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26199092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26199092"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mrinal K Das, Herman S F Evensen, Kari Furu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-302s may act as oncogenes in human testicular germ cell tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-45573-6"}], "href": "https://doi.org/10.1038/s41598-019-45573-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235829"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jun-Jie Ye, Yan-Lei Cheng, Jun-Jian Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00460 promotes tumor growth of human lung adenocarcinoma by targeting miR-302c-5p/FOXA1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.10.058"}], "href": "https://doi.org/10.1016/j.gene.2018.10.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30359741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30359741"}]}]}]}
Synonyms MIR-302C, MIRN302C
NCBI Gene ID 442895
API
Download Associations
Predicted Functions View MIR302C's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR302C's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR302C's ARCHS4 Predicted Functions.

Functional Associations

MIR302C has 403 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR302C from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR302C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR302C gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR302C gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR302C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR302C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR302C gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR302C from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR302C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR302C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR302C gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR302C gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.