{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑302e is emerging as a critical regulator in oncogenesis. In colorectal cancer, miR‑302e normally targets pro‑tumorigenic factors; however, its suppression by the long noncoding RNA FGD5‑AS1 results in the derepression of CDCA7, thereby enhancing cell proliferation, migration, invasion, and reducing apoptosis. Similarly, in ovarian cancer, the circular RNA circRhoC functions as a sponge for miR‑302e, leading to increased VEGFA expression and facilitating tumor cell viability, migration, invasion, and peritoneal dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of allergic inflammation, miR‑302e plays an anti‑inflammatory role in human mast cells. It is the predominant member of the miR‑302 family expressed in these cells and functions by directly targeting RelA, a key activator of the NF‑κB pathway. Overexpression of miR‑302e suppresses the production of inflammatory cytokines such as IL‑1β, IL‑6, TNF‑α, and thymic stromal lymphopoietin in response to allergen or pharmacologic stimulation, highlighting its potential as a therapeutic target for allergic diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neuronal cells, miR‑302e is implicated in mediating sevoflurane‑induced neurotoxicity. Exposure to sevoflurane increases miR‑302e levels in human hippocampal cells, which in turn directly targets and downregulates the oxidation resistance gene OXR1. This downregulation is associated with decreased cell viability, increased markers of oxidative stress, calcium dysregulation, and enhanced apoptosis. Conversely, inhibition of miR‑302e or overexpression of OXR1 confers protection against sevoflurane‑induced cytotoxic effects, underscoring the role of the miR‑302e/OXR1 axis in neuroprotection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ding Li, Xiaohui Jiang, Xueliang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302e."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vitro Cell Dev Biol Anim (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11626-019-00376-x"}], "href": "https://doi.org/10.1007/s11626-019-00376-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31332696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31332696"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li-Li Wang, Zhi-Hong Zong, Yao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRhoC promotes tumorigenicity and progression in ovarian cancer by functioning as a miR-302e sponge to positively regulate VEGFA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14736"}], "href": "https://doi.org/10.1111/jcmm.14736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31639291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31639291"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lifeng Xiao, Li Jiang, Qi Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-302e attenuates allergic inflammation "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " model by targeting RelA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20180025"}], "href": "https://doi.org/10.1042/BSR20180025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748238"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Leilei Yang, Qian Shen, Yanqiong Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9442"}], "href": "https://doi.org/10.3892/mmr.2018.9442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30221705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30221705"}]}]}]}