MIR302F Gene

HGNC Family Non-coding RNAs
Name microRNA 302f
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent genomic studies have uncovered that copy‐number variants near MIR302F are recurrently detected in patients with classic heterotaxy, a disorder associated with congenital heart defects and disrupted left–right body axis formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " These findings suggest that MIR302F may play a regulatory role in the expression of genes involved in key body patterning pathways—including components of the NODAL, BMP, and WNT signaling cascades—that are critical for proper cardiac development and the establishment of left–right asymmetry. The identification of these CNVs underscores the possibility that differential dosage or altered function of MIR302F contributes to an increased susceptibility to heterotaxy, thereby warranting further investigation into its mechanistic role in developmental gene regulation.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Erin M Hagen, Robert J Sicko, Denise M Kay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-016-1727-x"}], "href": "https://doi.org/10.1007/s00439-016-1727-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27637763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27637763"}]}]}]}
Synonyms MIRN302F, HSA-MIR-302F
NCBI Gene ID 100302131
API
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Predicted Functions View MIR302F's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR302F's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR302F's ARCHS4 Predicted Functions.

Functional Associations

MIR302F has 180 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR302F from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR302F gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR302F gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR302F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR302F gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR302F gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR302F gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR302F gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR302F gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR302F gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR302F gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR302F gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR302F gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.