{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the tumor‐suppressive functions of miR‑3064‑5p in several cancer types. In hepatocellular carcinoma, miR‑3064‑5p is downregulated, and its loss is associated with enhanced angiogenesis through the inhibition of proangiogenic factors like VEGFA and angiogenin alongside the activation of antiangiogenic molecules; mechanistically, it suppresses the FOXA1/CD24/Src pathway, an effect that is counteracted by the oncogenic lncRNA MALAT1 acting as a sponge."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In ovarian cancer, miR‑3064‑5p (together with miR‑532) is also downregulated and exerts its tumor‐suppressive role by directly targeting the 3′‑UTR of hTERT, leading to the inhibition of proliferation, epithelial–mesenchymal transition, and invasive capabilities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of pancreatic cancer, although miR‑3064‑5p has been recognized as an important tumor suppressor in ovarian cancer, its specific roles, downstream targets, and upstream regulators in pancreatic malignancy remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in colorectal cancer, miR‑3064‑5p is suppressed by the upregulation of the long non‑coding RNA LINC00958; release of miR‑3064‑5p leads to the downregulation of LEMD1 and subsequent inactivation of PI3K/AKT signaling, thereby inhibiting tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in bladder cancer, miR‑3064‑5p is sequestered by the lncRNA LINC00858, which in turn relieves its suppression of the oncogene CTGF. This interaction contributes to enhanced cellular proliferation, migration, and invasion. Collectively, these findings underscore miR‑3064‑5p as an integral tumor suppressor whose downregulation or functional inhibition via sponging by oncogenic long non‑coding RNAs contributes to the activation of multiple oncogenic pathways. Its consistent association with favorable clinical outcomes when expressed at higher levels positions miR‑3064‑5p as not only a promising prognostic biomarker but also a potential therapeutic target in diverse malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pei Zhang, Mei Ha, Lianbing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3064-5p sponged by MALAT1 suppresses angiogenesis in human hepatocellular carcinoma by targeting the FOXA1/CD24/Src pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201901834R"}], "href": "https://doi.org/10.1096/fj.201901834R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31914639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31914639"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lin Bai, Hui Wang, Ai-Hua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0173912"}], "href": "https://doi.org/10.1371/journal.pone.0173912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28291810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28291810"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiayan Yan, Yunxi Jia, Han Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1379-5"}], "href": "https://doi.org/10.1186/s13046-019-1379-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31488171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31488171"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhaoxia Luo, Shunxin Hao, Jian Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1985259"}], "href": "https://doi.org/10.1080/21655979.2021.1985259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34672237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34672237"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ji Huang, Qiu-Ming He, Qi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA 00858 knockdown alleviates bladder cancer via regulation of the miR‑3064‑5p/CTGF axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8115"}], "href": "https://doi.org/10.3892/or.2021.8115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34132366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34132366"}]}]}]}