{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR3065 has been implicated in regulating cancer stem‐related traits in colorectal cancer. In particular, studies have identified a specific isoform, miR‑3065‑3p, that can modulate the stemness of colorectal cancer cells, suggesting that MIR3065 may be involved in controlling cellular differentiation pathways and self‑renewal properties that contribute to tumor initiation and progression. This regulation of stemness could potentially influence the aggressiveness and treatment responses in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the glioblastoma microenvironment, a different isoform, miR‑3065‑5p, has been shown to play a critical role in tumor–stroma interactions. Glioma stem cell–derived exosomes deliver miR‑3065‑5p to normal human astrocytes, thereby promoting their transformation into tumor‐associated astrocytes (TAAs). This transfer leads to enhanced astrocyte proliferation, increased chemoresistance (notably to temozolomide), and upregulation of markers associated with the tumor‐promoting phenotype through the suppression of the tumor suppressor DLG2. This exosome‐mediated reprogramming by MIR3065 contributes to the supportive microenvironment that favors glioblastoma development and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yifan Li, Jing Xun, Botao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-03102-y"}], "href": "https://doi.org/10.1186/s12967-021-03102-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34656128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34656128"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuting Yu, ZhiYong Sun, Tiantian Ju, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202308769"}], "href": "https://doi.org/10.1002/advs.202308769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38810124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38810124"}]}]}]}