MIR3074 Gene

HGNC Family Non-coding RNAs
Name microRNA 3074
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Overexpression studies in human trophoblast cells have revealed that miR-3074‑5p modulates cell behavior, later shown to promote apoptosis while inhibiting cellular invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in human endometrial stromal cells, elevated miR-3074‑5p impairs decidualization—a key process for establishing pregnancy—by suppressing cell proliferation and downregulating cell cycle regulators, mediated at least in part through its direct targeting of CLN8."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Complementary findings in extravillous trophoblasts further indicate that miR-3074‑5p disrupts normal cell function by reducing GDF15 production via direct inhibition of EIF2S1, thereby contributing to defective trophoblast proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond reproductive contexts, miR-3074‑5p has been implicated in the regulation of cell proliferation and migration in diverse disease settings. In psoriasis, a competitive endogenous RNA network has been described where the snoRNA Snora73 acts as a sponge for miR-3074‑5p; in this setting, miR-3074‑5p exerts inhibitory effects on cell proliferation and migration by directly targeting PBX1, thereby influencing disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, studies in non‑small cell lung cancer have shown that miR-3074‑5p functions as a tumor suppressor: its overexpression leads to reduced cell proliferation, migration, and invasion, and it enhances chemotherapeutic responses by targeting YWHAZ and affecting Hsp27 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cardiovascular arena, the involvement of miR-3074‑5p extends to the regulation of apoptosis in macrophages within atherosclerotic lesions. Here, circRNA‑mediated sponging of miR-3074‑5p modulates the Notch signaling pathway by derepressing DLL4, thereby contributing to nicotine‑induced macrophage apoptosis and potentially influencing atherogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elkin Navarro-Quiroz, Lisandro Pacheco-Lugo, Hernan Lorenzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0166202"}], "href": "https://doi.org/10.1371/journal.pone.0166202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27835701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27835701"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Gu, Yan Shi, Qian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3074-5p Promotes the Apoptosis but Inhibits the Invasiveness of Human Extravillous Trophoblast-Derived HTR8/SVneo Cells In Vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1933719117725823"}], "href": "https://doi.org/10.1177/1933719117725823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28826362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28826362"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nan Meng, Xinyue Wang, Yan Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3074-5p/CLN8 pathway regulates decidualization in recurrent miscarriage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reproduction (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/REP-21-0032"}], "href": "https://doi.org/10.1530/REP-21-0032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34044364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34044364"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jia-Xin Shi, Long Yang, Jie Gan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-023-01436-0"}], "href": "https://doi.org/10.1007/s43032-023-01436-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38151653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38151653"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lihua Zhang, Hui Guo, Xiaoguang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-024-01300-7"}], "href": "https://doi.org/10.1007/s10142-024-01300-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38240925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38240925"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nian Dong, Wen-Wen Gu, Long Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3074-5p suppresses non-small cell lung cancer progression by targeting the YWHAZ/Hsp27 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2024.112547"}], "href": "https://doi.org/10.1016/j.intimp.2024.112547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38943969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38943969"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lin Cong, Lili Zhao, Ying Shi, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Circ_0006476"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " modulates macrophage apoptosis through the miR-3074-5p/DLL4 axis: implications for Notch signalling pathway regulation in cardiovascular disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.206049"}], "href": "https://doi.org/10.18632/aging.206049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39167432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39167432"}]}]}]}
Synonyms MIR-3074
NCBI Gene ID 100422842
API
Download Associations
Predicted Functions View MIR3074's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3074's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3074's ARCHS4 Predicted Functions.

Functional Associations

MIR3074 has 625 functional associations with biological entities spanning 5 categories (molecular profile, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR3074 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3074 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3074 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3074 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3074 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3074 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3074 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3074 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR3074 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR3074 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR3074 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3074 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3074 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3074 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3074 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR3074 protein from the Wikipathways Pathways 2014 dataset.