{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that MIR3117 is upregulated in hepatocellular carcinoma tissues and cell lines, where it contributes to tumorigenesis by enhancing cancer cell proliferation. Functional assays, including MTT, BrdU, soft agar growth, and cell cycle analyses, demonstrated that overexpression of MIR3117 in HepG2 cells accelerates proliferation, while its knockdown leads to reduced cell growth. Mechanistic studies further identified that MIR3117 directly targets the 3′UTR of the PH domain and leucine-rich repeat protein phosphatase-like (PHLPPL) gene, implying that by suppressing PHLPPL, MIR3117 plays an oncogenic role and represents a potential target for therapeutic intervention in hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "MicroRNAs, as a class, are critical regulators of cancer cell susceptibility and development, influencing various cellular processes that underpin tumor initiation and progression. Their ability to modulate gene expression post-transcriptionally highlights the importance of understanding each miRNA’s role, including that of MIR3117, in the complex network governing oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In addition, genetic variations such as single-nucleotide polymorphisms in microRNAs can substantially alter their function and downstream target gene expression, thereby affecting disease susceptibility and progression. These findings underscore the significance of investigating MIR3117 not only in hepatocellular carcinoma but also in other malignancies such as pediatric acute lymphoblastic leukemia, where altered miRNA profiles may contribute to disease pathogenesis and offer novel avenues for risk stratification and therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xia Cui, Qingyan Li, Yukai He "}, {"type": "b", "children": [{"type": "t", "text": "miR-3117 regulates hepatocellular carcinoma cell proliferation by targeting PHLPPL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-016-2855-2"}], "href": "https://doi.org/10.1007/s11010-016-2855-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27822662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27822662"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sahel Sarabandi, Hedieh Sattarifard, Mohammad Kiumarsi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2021.22.1.201"}], "href": "https://doi.org/10.31557/APJCP.2021.22.1.201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33507700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33507700"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Miriam Fabiola Ayón-Pérez, Yazmín Gómez-Gómez, Jorge Organista-Nava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of MIR3117 and MIR612 Genes Polymorphisms with Childhood Acute Lymphoblastic Leukemia in the Mexican Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.arcmed.2022.07.004"}], "href": "https://doi.org/10.1016/j.arcmed.2022.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36002354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36002354"}]}]}]}