{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research has revealed that the long noncoding RNA HAND2‐AS1, which is downregulated in breast cancer cells, plays a tumor‐suppressive role by negatively regulating miR‑3118. In this context, HAND2‑AS1 acts as a molecular sponge, reducing the elevated levels of miR‑3118 observed in breast cancer, which is crucial for mitigating cancer cell proliferation, migration, and invasion, while simultaneously promoting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nMechanistic investigations have further demonstrated that the downregulation of miR‑3118 by HAND2‑AS1 indirectly leads to the increased expression of PHLPP2, a downstream target that contributes to the suppression of breast cancer progression. The depletion of miR‑3118 itself was sufficient to constrain malignant behaviors in breast cancer cells, underscoring miR‑3118’s role as a facilitator of oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nTogether, these findings highlight the critical function of the HAND2‑AS1/miR‑3118/PHLPP2 regulatory axis in breast cancer pathogenesis and suggest that targeting miR‑3118 could represent a promising therapeutic strategy to control tumor growth and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guolei Dong, Xiaorui Wang, Yan Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HAND2-AS1 Works as a ceRNA of miR-3118 to Suppress Proliferation and Migration in Breast Cancer by Upregulating PHLPP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8124570"}], "href": "https://doi.org/10.1155/2020/8124570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015182"}]}]}]}