MIR3119-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 3119-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts reveals that while several studies offer detailed insights into adipocyte cell surface markers and proton‐coupled amino acid transport mechanisms, none of these reports explicitly describe or characterize a function for MIR3119‑1. In one study, distinct membrane proteins—ASC‑1 for white adipocytes and PAT2 along with P2RX5 for brown/beige adipocytes—were identified as potential diagnostic and therapeutic targets in both murine and human tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Another investigation focused on the PAT2 transporter, demonstrating via electrophysiological and flux experiments in Xenopus laevis oocytes that it functions as a proton/amino acid symporter with stringent substrate specificity and pH‑dependent modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In a separate report, analyses of lipid storage droplets in fetal membranes highlighted the heterogeneous association of PAT family proteins (ADRP, TIP47, and a small isoform of perilipin), suggesting specialized roles of these proteins in different cell types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, studies using differentiated 3T3‑L1 adipocytes reinforced the presence and function of PAT2 as a proton gradient–stimulated transporter for amino acids such as L‑proline."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Overall, although these studies provide a comprehensive analysis of certain adipocyte membrane proteins and transporters, none address or elucidate the function of MIR3119‑1. \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Siegfried Ussar, Kevin Y Lee, Simon N Dankel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3008490"}], "href": "https://doi.org/10.1126/scitranslmed.3008490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25080478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25080478"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martin Foltz, Carmen Oechsler, Michael Boll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Biochem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1432-1033.2004.04268.x"}], "href": "https://doi.org/10.1111/j.1432-1033.2004.04268.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15291811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15291811"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "W E Ackerman, J M Robinson, D A Kniss "}, {"type": "b", "children": [{"type": "t", "text": "Association of PAT proteins with lipid storage droplets in term fetal membranes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2006.06.009"}], "href": "https://doi.org/10.1016/j.placenta.2006.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16965813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16965813"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Katja Zebisch, Matthias Brandsch "}, {"type": "b", "children": [{"type": "t", "text": "Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-012-1340-9"}], "href": "https://doi.org/10.1007/s00726-012-1340-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22711289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22711289"}]}]}]}
NCBI Gene ID 100422839
API
Download Associations
Predicted Functions View MIR3119-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3119-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3119-1's ARCHS4 Predicted Functions.

Functional Associations

MIR3119-1 has 195 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3119-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3119-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3119-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3119-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3119-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3119-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3119-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3119-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR3119-1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3119-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3119-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.