{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR3120 is a microRNA with multifaceted roles in the regulation of cell migration, angiogenesis, tumor cell stemness, and invasion. In endothelial progenitor cells, MIR3120-5p functions as a regulatory component within a molecular decoy system involving the long noncoding RNA WTAPP1. Here, MIR3120-5p binding to WTAPP1 results in the downregulation of MMP-1 expression and modulation of the PI3K/Akt/mTOR signaling and autophagy pathways, thereby affecting EPC migration, invasion, and angiogenic tube formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several cancer types, altered MIR3120-5p expression plays critical roles in tumor progression. In colon cancer, high MIR3120-5p levels promote cancer stem cell properties and invasiveness by directly targeting Axin2, which contributes to tumor recurrence and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in non‐small cell lung cancer, upregulation of MIR3120-5p fosters cell proliferation, enhances colony formation, and accelerates cell cycle progression by repressing the tumor suppressor KLF4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, in gallbladder cancer, the miR‐214/3120 cluster functions in a tumor‐suppressive manner by targeting E2F3 to inhibit both epithelial‐to‐mesenchymal transition (EMT) and autophagy, thereby curbing tumorigenicity and metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, the diagnostic potential of MIR3120 has been highlighted in the context of lung squamous cell carcinoma. Elevated levels of MIR3120 detected in serum extracellular vesicles provide a promising noninvasive biomarker to distinguish primary lung squamous cell carcinoma from metastatic lesions originating in head and neck squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wen-Dong Li, Dong-Ming Zhou, Li-Li Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA WTAPP1 Promotes Migration and Angiogenesis of Endothelial Progenitor Cells via MMP1 Through MicroRNA 3120 and Akt/PI3K/Autophagy Pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2904"}], "href": "https://doi.org/10.1002/stem.2904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30171660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30171660"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Hongdan, Li Feng "}, {"type": "b", "children": [{"type": "t", "text": "miR-3120-5p promotes colon cancer stem cell stemness and invasiveness through targeting Axin2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.01.021"}], "href": "https://doi.org/10.1016/j.bbrc.2018.01.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29307822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29307822"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongwei Xu, Quan Wen "}, {"type": "b", "children": [{"type": "t", "text": "miR‑3120‑5p acts as a diagnostic biomarker in non‑small cell lung cancer and promotes cancer cell proliferation and invasion by targeting KLF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9454"}], "href": "https://doi.org/10.3892/mmr.2018.9454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30221715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30221715"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wujun Li, Pu Yan, Xiaofen Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The microRNA cluster miR-214/miR-3120 prevents tumor cell switching from an epithelial to a mesenchymal-like phenotype and inhibits autophagy in gallbladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2020.109887"}], "href": "https://doi.org/10.1016/j.cellsig.2020.109887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33340658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33340658"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yoshihisa Shimada, Jun Matsubayashi, Akira Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small RNA sequencing to differentiate lung squamous cell carcinomas from metastatic lung tumors from head and neck cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0248206"}], "href": "https://doi.org/10.1371/journal.pone.0248206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33668046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33668046"}]}]}]}