MIR3124 Gene

HGNC Family Non-coding RNAs
Name microRNA 3124
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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This action inhibits microglial activation, reduces neuronal apoptosis, and ultimately protects dopaminergic neurons from degeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the vascular context, down‐regulation of miR‐190a in endothelial cells contributes to insulin resistance. Here, reduced miR‐190a facilitates a sustained activation of ERK1/2 and increased KRAS expression, thereby impairing the insulin signaling cascade. Restoring miR‐190a levels mitigates these effects and improves endothelial function, highlighting its therapeutic promise for diabetic vascular complications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nScreening studies for postoperative cognitive dysfunction have also implicated miRNAs in the regulation of hippocampal gene networks underlying cognitive decline. Although the specific targets were not detailed, these findings underscore the broader relevance of miRNA-mediated regulation in neurocognitive disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn liver fibrosis, the miR‐190a-5p/HGF axis has emerged as a critical regulator of hepatocyte apoptosis. Resveratrol-mediated upregulation of miR‐190a-5p appears to attenuate fibrosis by enhancing HGF expression, suggesting that miR‐190a-5p serves as a protective factor in hepatic injury and repair processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of ischemic acute kidney injury, a circRNA (circRNA_45478) contributes to tubular cell apoptosis by functioning as a sponge for miR‐190a-5p. This sequestration results in the upregulation of PHLPP1 and exacerbates cell death, indicating that preserving miR‐190a-5p activity might offer a novel approach to ameliorate kidney injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, in pancreatic β-cells, glucotoxicity-induced downregulation of miR‐190 is linked to cellular dysfunction. Restoration of miR‐190 levels improves insulin secretion and attenuates reactive oxygen species generation by targeting Cybb, a subunit of the NOX2 complex. These findings emphasize the potential of miR‐190 to protect β-cell function in type 2 diabetes mellitus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui Zheng, Yan Zeng, Xiaoxiao Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28907"}], "href": "https://doi.org/10.1002/jcp.28907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31232472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31232472"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Paola Mirra, Cecilia Nigro, Immacolata Prevenzano, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-019-6035-0"}], "href": "https://doi.org/10.1186/s12864-019-6035-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31438846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31438846"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Feiyu Liang, Xiaozuo Xu, Yanyan Tu "}, {"type": "b", "children": [{"type": "t", "text": "Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioorg Med Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bmc.2021.116593"}], "href": "https://doi.org/10.1016/j.bmc.2021.116593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35093804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35093804"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yingjun Liao, Xiongjun Peng, Xiaozhou Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-190 ameliorates glucotoxicity-induced dysfunction and apoptosis of pancreatic "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "β"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-cells by inhibiting NOX2-mediated reactive oxygen species production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.13849"}], "href": "https://doi.org/10.7717/peerj.13849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35971429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35971429"}]}]}]}
Synonyms MIR-3124
NCBI Gene ID 100422879
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Download Associations
Predicted Functions View MIR3124's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3124's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3124's ARCHS4 Predicted Functions.

Functional Associations

MIR3124 has 1,065 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR3124 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3124 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3124 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3124 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing MIR3124 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3124 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3124 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3124 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3124 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3124 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3124 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3124 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3124 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of MIR3124 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.