{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that in colon cancer, LINC01207 acts as an oncogenic long noncoding RNA by sponging miR-3125, a microRNA that normally functions to negatively regulate the expression of the oncogene TRIM22. In colon adenocarcinoma tissues, the upregulation of LINC01207 leads to a decrease in the free pool of miR-3125, thereby relieving its repression on TRIM22 and promoting cellular proliferation, migration, and invasion. Notably, experimental silencing of LINC01207 in colon cancer cell lines significantly impairs these malignant behaviors, and the subsequent inhibition of miR-3125 or the overexpression of TRIM22 can rescue the suppressed growth and invasion phenotypes. These results collectively underscore the critical role of the LINC01207/miR-3125/TRIM22 regulatory axis in colon cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ronghong Liu, Wenzeng Zhao, Haigang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC01207 Promotes Colon Cancer Cell Proliferation and Invasion by Regulating miR-3125/TRIM22 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/1216325"}], "href": "https://doi.org/10.1155/2020/1216325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33299853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33299853"}]}]}]}