{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence indicates that MIR3126‐5p functions as a promising circulating biomarker in hepatocellular carcinoma (HCC). In a study screening both cell culture supernatants and patient sera, MIR3126‐5p, along with miR‐92‐3p and miR‐107, was found to be significantly dysregulated in HCC compared to controls. Logistic regression analysis demonstrated that a panel combining these three microRNAs achieved very high diagnostic accuracy—an area under the curve of 0.975 for early‐stage HCC and 0.971 for patients with low‐level alpha‐fetoprotein. Moreover, when this three‐microRNA panel was used in combination with AFP measurements, the ability to discriminate HCC, particularly among early‐stage or AFP‐low patients, was further enhanced. These findings suggest that MIR3126‐5p plays a key role in the non‐invasive detection of HCC, underscoring its potential clinical utility as part of a diagnostic signature for early tumor screening."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Zhang, Tao Li, Yumin Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000005642"}], "href": "https://doi.org/10.1097/MD.0000000000005642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28079796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28079796"}]}]}]}