{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence in hepatocellular carcinoma (HCC) indicates that miR‐3129, particularly its 5p strand, plays a pivotal role in modulating chemoresistance and metastatic potential. In one study, upregulation of the long non‐coding RNA MALAT1 in doxorubicin‐resistant HCC cells was found to sponge miR‐3129-5p, thereby releasing its repression on Nova1. This regulatory axis promoted cell proliferation, migration, invasion, and ultimately contributed to doxorubicin resistance. In a related investigation, HCC‐derived extracellular vesicles were shown to deliver miR‐3129, suggesting that intercellular transfer of this miRNA may further influence HCC progression and dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn epithelial ovarian cancer (EOC), miR‐3129 functions as an important tumor suppressor. Functional assays demonstrated that miR‐3129 directly binds to the 3′ untranslated region of CD44 mRNA. Overexpression of miR‐3129 in EOC cell lines led to reduced CD44 levels, which in turn inhibited cell proliferation and altered the response to the chemotherapeutic agent bufalin. Importantly, ectopic overexpression of CD44 reversed the anti-cancer effects elicited by miR‐3129 upregulation, underscoring its role in modulating CD44‐mediated oncogenic pathways in EOC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer biology, altered expression of miR‐3129 has also been linked to cardiovascular pathology. Clinical profiling revealed that serum levels of miR‐3129-5p are elevated in patients with coronary heart disease (CHD) and correlate with the severity of arterial stenosis. Mechanistic studies identified mTOR as a direct target of miR‐3129-5p; suppression of mTOR signaling led to decreased phosphorylation of S6 and increased autophagy, as evidenced by elevated LC3II/LC3I and Beclin1 expression. These findings suggest that miR‐3129 may serve both as a biomarker and a potential therapeutic target in CHD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yongxian Cao, Feng Zhang, Haotian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MALAT1 mediates doxorubicin resistance of hepatocellular carcinoma by regulating miR-3129-5p/Nova1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-020-03904-6"}], "href": "https://doi.org/10.1007/s11010-020-03904-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32965597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32965597"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Yang, Feifei Mao, Lei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor cells derived-extracellular vesicles transfer miR-3129 to promote hepatocellular carcinoma metastasis by targeting TXNIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Liver Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dld.2021.01.003"}], "href": "https://doi.org/10.1016/j.dld.2021.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33563583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33563583"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaochun Sun, Manhua Cui, Lingling Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of microRNA-3129 suppresses epithelial ovarian cancer through CD44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-018-0026-1"}], "href": "https://doi.org/10.1038/s41417-018-0026-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29915283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29915283"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhen-Yu Wang, Ting Zhao, Jing Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated serum miR-3129-5p contributes to the progression of coronary heart disease via targeting mTOR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12333"}], "href": "https://doi.org/10.1002/kjm2.12333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33336524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33336524"}]}]}]}