MIR3130-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 3130-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified a crucial role for MIR3130-1 (the gene encoding microRNA miR-3130-3p) in modulating cancer cell behavior. In triple‐negative breast cancer, work suggests that lncRNA LINC01096 may interact with miR-3130-3p to influence cell viability, apoptosis, migration, and invasion, indicating that MIR3130-1 functions as a regulatory node in key oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In prostate cancer, elevated levels of the lncRNA FOXP4-AS1 act as a competing endogenous RNA that sponges miR-3130-3p, thereby alleviating its suppression of the transcription factor SP4. This de-repression of SP4 promotes tumor cell proliferation and growth, while SP4 in turn enhances FOXP4-AS1 transcription—establishing a positive feedback loop that exacerbates tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G-P Wang, Z-L Mou, Y-Y Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01096 knockdown inhibits progression of triple-negative breast cancer by increasing miR-3130-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201909_18854"}], "href": "https://doi.org/10.26355/eurrev_201909_18854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31539132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31539132"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tingting Gu, Huafeng Pan, Fei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2022.68.10.24"}], "href": "https://doi.org/10.14715/cmb/2022.68.10.24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37114256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37114256"}]}]}]}
Synonyms MIR3130-3, MIR-3130-1
NCBI Gene ID 100422993
API
Download Associations
Predicted Functions View MIR3130-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3130-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3130-1's ARCHS4 Predicted Functions.

Functional Associations

MIR3130-1 has 503 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3130-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3130-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3130-1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3130-1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3130-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3130-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3130-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3130-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3130-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3130-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3130-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.