{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn triple‐negative breast cancer (TNBC), recent work has explored the interaction between long noncoding RNA LINC01096 and microRNA miR‑3130‑3p. The study assessed how LINC01096 influences key cellular processes such as viability, apoptosis, migration, and invasion, suggesting that LINC01096 may modulate TNBC progression by interacting with miR‑3130‑3p, although the precise downstream targets of miR‑3130‑3p in this context remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In prostate cancer (PCa), a complementary study demonstrated that the long noncoding RNA FOXP4‐AS1 acts as a competing endogenous RNA (ceRNA) to sequester miR‑3130‑3p. This sponging action relieves the inhibitory effect of miR‑3130‑3p on the transcription factor SP4, thereby promoting cell proliferation and tumor growth. In an intriguing feedback loop, SP4 was further shown to activate FOXP4‐AS1 transcription, underlining the role of miR‑3130‑3p as a negative regulator in PCa tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Collectively, these studies underscore the context‐dependent tumor suppressor function of miR‑3130‑3p. In TNBC, its interaction with LINC01096 suggests a potential role in regulating malignancy‐associated cellular behaviors, while in PCa, miR‑3130‑3p’s suppression of SP4 is counteracted by FOXP4‑AS1, thereby facilitating tumor progression. These findings highlight the therapeutic potential of targeting lncRNA–miRNA regulatory axes in diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G-P Wang, Z-L Mou, Y-Y Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01096 knockdown inhibits progression of triple-negative breast cancer by increasing miR-3130-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201909_18854"}], "href": "https://doi.org/10.26355/eurrev_201909_18854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31539132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31539132"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tingting Gu, Huafeng Pan, Fei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2022.68.10.24"}], "href": "https://doi.org/10.14715/cmb/2022.68.10.24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37114256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37114256"}]}]}]}