{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies have demonstrated that polymorphisms in the precursor of miR-3131 can significantly alter its maturation and expression, contributing to cancer susceptibility. In particular, an insertion/deletion polymorphism (rs57408770) in pre‐miR‐3131 was shown to affect the binding of the splicing factor SRp20, leading to an increased expression of mature miR‐3131. The resulting overexpression enhances cell proliferation and inhibits apoptosis, in part by downregulating target mRNAs such as DTHD1 and XAF1, which are likely involved in tumor suppression, thereby promoting hepatocellular carcinoma initiation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe mechanistic insights from these findings support a proto‐oncogenic role for miR‐3131 in hepatocellular carcinoma, emphasizing the importance of post‐transcriptional regulation in carcinogenesis. The altered activity of miR‐3131, mediated by its genetic polymorphisms, underscores how disruptions in miRNA processing can have far‐reaching effects on downstream gene expression and tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, research has also begun to explore the clinical significance of the pre‐miR‐3131 3‐bp insertion/deletion polymorphism in the context of breast cancer susceptibility. Although the full spectrum of its functional impact in breast cancer remains to be elucidated, these studies suggest that genetic alterations affecting miR‐3131 expression may be an important risk factor across multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chaoqun Wang, Lijuan Li, Zhixia Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An indel polymorphism within pre-miR3131 confers risk for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgw206"}], "href": "https://doi.org/10.1093/carcin/bgw206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28034876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28034876"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mahsa Azizi, Nahid Rahimi, Gholamreza Bahari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microrna (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/2211536608666190906111830"}], "href": "https://doi.org/10.2174/2211536608666190906111830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31490768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31490768"}]}]}]}