{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNAs are emerging as key regulators in various cardiometabolic disorders, serving as both functional modulators and biomarkers. In a study focused on gestational diabetes mellitus, researchers explored the potential role of miRNAs in regulating serum lipids and blood glucose levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the work on gestational diabetes did not single‐out a specific miRNA, it underscored the broader importance of miRNAs in metabolic regulation—a context within which MIR3135B may be implicated.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, the investigation into severe hypertension directly identified MIR3135B as a differentially expressed circulating miRNA. Patients with severe hypertension exhibited distinct expression levels of MIR3135B relative to healthy controls, suggesting that MIR3135B could serve as a potential biomarker for the condition. Moreover, the differential regulation of its independent target genes hints at a functional role in the pathophysiology of hypertension."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these studies propose that while the precise mechanistic contribution of MIR3135B to metabolic processes remains to be fully elucidated, its altered expression in severe hypertension highlights a promising potential for diagnostic or prognostic utility. The integration of these findings emphasizes a broader theme: specific miRNAs such as MIR3135B may have distinct regulatory roles depending on the pathological context, ranging from subtle effects in metabolic regulation to a clear marker in cardiovascular dysregulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fuyan Wang, Zhulin Li, Ming Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miRNAs miR-574-5p and miR-3135b are potential metabolic regulators for serum lipids and blood glucose in gestational diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Endocrinol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09513590.2021.1908990"}], "href": "https://doi.org/10.1080/09513590.2021.1908990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34126831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34126831"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jikang Shi, Yaxuan Ren, Yunkai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-3135b and miR-107 are potential biomarkers for severe hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Hypertens (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41371-020-0338-0"}], "href": "https://doi.org/10.1038/s41371-020-0338-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32327699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32327699"}]}]}]}