| HGNC Family | Non-coding RNAs |
| Name | microRNA 3137 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent microarray-based analysis of urinary microRNA expression in diabetic kidney disease (DKD) revealed that MIR3137 is differentially expressed, suggesting that this miRNA may participate in molecular pathways related to renal dysfunction linked with diabetes. Its altered expression profile indicates that MIR3137 could serve as a promising biomarker, potentially complementing traditional diagnostic measures such as the albumin-to-creatinine ratio, whose predictive power is limited. These findings highlight the potential utility of MIR3137 in improving early detection and risk stratification in DKD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyu Li, Rong Xu, Xiangyang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary miR-3137 and miR-4270 as potential biomarkers for diabetic kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23549"}], "href": "https://doi.org/10.1002/jcla.23549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32869917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32869917"}]}]}]}
|
| NCBI Gene ID | 100422926 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
MIR3137 has 101 functional associations with biological entities spanning 1 categories (cell line, cell type or tissue) extracted from 1 datasets.
Click the + buttons to view associations for MIR3137 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3137 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |