{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn pediatric dysembryoplastic neuroepithelial tumors (DNETs), miR‑3138 has been identified as a microRNA with a potential tumor suppressor role. Expression profiling using miRNA microarrays revealed that levels of miR‑3138 are significantly lower in tumor samples compared to controls. This reduction in miR‑3138 expression suggests that under normal conditions it may help prevent abnormal cellular proliferation or other oncogenic processes, and its down‐regulation could contribute to tumor development in the pediatric central nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the altered expression of miR‑3138 in these tumors indicates its promise as a diagnostic biomarker in pediatric DNETs. In the study, the down‐regulation of miR‑3138—as opposed to the up‐regulation observed for other miRNAs with putative oncogenic activity—underscored its potential role in tumor suppression, thereby providing a rationale for further investigation into its utility for both diagnosis and possible therapeutic targeting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Braoudaki, G I Lambrou, S A Papadodima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-015-0719-3"}], "href": "https://doi.org/10.1007/s12032-015-0719-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26698155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26698155"}]}]}]}