{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings indicate that MIR3142HG may play a role in oncogenesis, as genetic variants within this non‐coding RNA gene have been associated with altered susceptibility to glioma as well as differences in patient prognosis. These observations suggest that MIR3142HG could influence tumor biology and the clinical outcomes of glioma patients by modulating gene regulatory networks implicated in cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, functional studies in models of acute lung injury have demonstrated that MIR3142HG expression is upregulated following lipopolysaccharide (LPS) exposure in human pulmonary microvascular endothelial cells. Elevated MIR3142HG levels appear to exacerbate cell apoptosis and the inflammatory response by impairing the miR-450b-5p–mediated suppression of high-mobility group box 1 (HMGB1). Conversely, MIR3142HG knockdown effectively alleviated LPS-induced injury, indicating that this long non-coding RNA is a critical regulator of inflammation and cell survival in the context of lung injury and might represent a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoye Guo, Ming Zhang, Qi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of Genetic Variants in MIR3142HG in Susceptibility to and Prognosis of Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/COC.0000000000000587"}], "href": "https://doi.org/10.1097/COC.0000000000000587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31513017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31513017"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaolei Gong, Limin Zhu, Jinlong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR3142HG promotes lipopolysaccharide-induced acute lung injury by regulating miR-450b-5p/HMGB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-021-04209-y"}], "href": "https://doi.org/10.1007/s11010-021-04209-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34338955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34338955"}]}]}]}