{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered an antiviral and tumor‐suppressive role for miR-3144 in high-risk human papillomavirus (HR-HPV) infections. In particular, one study identified a conserved target site for miR-3144 within the E6 oncogene open reading frame of most HR-HPVs. Binding of miR-3144 to this region suppresses the expression of the viral E6 oncoprotein, thereby inhibiting cell growth and inducing apoptosis in HPV16-positive cervical cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \n \nRecent investigations into intestinal epithelial cell function have revealed complex regulatory networks that ensure mucosal immunity and barrier integrity. For example, the coordinated actions of proteins such as SAP-1 and CEACAM20 at the brush border help modulate cytokine production and immune responses in the gut, while microbial metabolites like butyrate further influence epithelial gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \n \nIn a related context of cancer biology, genetic variations affecting regulatory regions of immune-related receptors, such as a microRNA-associated single nucleotide polymorphism in the ERBB4 3'-UTR, have been linked to increased breast cancer risk. This underscores the broader significance of precise post-transcriptional regulation, akin to the tumor-suppressive mechanism enacted by miR-3144 in HR-HPV-associated cervical cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Lin, Qingqing Cai, Xiaoyan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-015-0142-8"}], "href": "https://doi.org/10.1007/s13238-015-0142-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25913515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25913515"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yoji Murata, Takenori Kotani, Yana Supriatna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1510167112"}], "href": "https://doi.org/10.1073/pnas.1510167112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26195794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26195794"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yasuaki Kitamura, Yoji Murata, Jung-Ha Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12247"}], "href": "https://doi.org/10.1111/gtc.12247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25908210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25908210"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Narges Zabihi, Samira Sadeghi, Hossein Tabatabaeian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association between rs1972820 and the risk of breast cancer in Isfahan population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/0973-1482.183202"}], "href": "https://doi.org/10.4103/0973-1482.183202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28508829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28508829"}]}]}]}