{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts explicitly mention MIR3147, one of them describes a closely related microRNA—miR‐13147—which, like many microRNAs, may play important roles in modulating cell signaling pathways in cancer. In vulvar squamous cell carcinoma (VSCC), miR‐13147 is markedly overexpressed and its increased levels correlate with deeper tissue invasion. Functional studies show that miR‐13147 promotes malignant behaviors by accelerating cell proliferation, migration, invasion, and G1/S cell cycle progression, in part by binding directly to the 3′ untranslated region of Smad4 and thereby suppressing key components of the transforming growth factor‑β/Smad signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, the abstracts also describe the role of interferon‑inducible guanylate binding protein 3 (GBP3) in various pathological contexts. In glioma and glioblastoma models, GBP3 is highly upregulated and drives tumor progression by inducing the expression of sequestosome‑1 (p62), which activates the ERK1/2 signaling cascade. This mechanism not only enhances cell proliferation but also contributes to chemoresistance by stabilizing STING protein and upregulating downstream effectors such as NRF2 and MGMT, ultimately reducing temozolomide‑induced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in a model of lupus nephritis, GBP3 exerts a pro‑inflammatory role by inhibiting cell proliferation while enhancing the expression of inflammatory cytokines and pyroptosis‑related proteins. This suggests that GBP3 can also modulate inflammatory pathways and cell death mechanisms in autoimmune conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, while none of these studies directly assess MIR3147, the functional characterization of miR‑13147 in VSCC hints at the possibility that closely related microRNAs may similarly regulate key cellular processes involved in tumor progression and inflammation. Moreover, the insights into GBP3’s role in both oncogenesis and immune‐mediated pathology further underscore the complexity of interferon‑regulated networks in disease. Further investigations are needed to elucidate whether MIR3147 shares any of these regulatory properties.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiu-Hua Yang, Feng Guo "}, {"type": "b", "children": [{"type": "t", "text": "miR‑3147 serves as an oncomiR in vulvar squamous cell cancer via Smad4 suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8697"}], "href": "https://doi.org/10.3892/mmr.2018.8697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29512734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29512734"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Xu, Lili Sun, Yanwen Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.11.050"}], "href": "https://doi.org/10.1016/j.bbrc.2017.11.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29128363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29128363"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hui Xu, Jing Jin, Ying Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02397-5"}], "href": "https://doi.org/10.1038/s41388-022-02397-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35780181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35780181"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhongfeng Zhang, Wenyu Song, Run Yan "}, {"type": "b", "children": [{"type": "t", "text": "Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autoimmunity (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/08916934.2023.2250095"}], "href": "https://doi.org/10.1080/08916934.2023.2250095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37621179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37621179"}]}]}]}