{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐3148 has emerged as an important post‐transcriptional regulator in immune function by targeting Toll-like receptor 7 (TLR7). Specifically, the non-risk allele of TLR7 contains a binding site for miR-3148, which facilitates transcript degradation and limits TLR7 expression. In contrast, the risk-associated allele shows reduced binding and slower degradation of TLR7 mRNA, leading to increased protein levels and a heightened risk for systemic lupus erythematosus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its immunoregulatory role, miR-3148 has been implicated in the pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH). Analyses of CTEPH samples revealed that miR-3148 is significantly downregulated compared with controls, and it regulates a large network of target genes. Notably, some of these targets, such as the androgen receptor (AR) and Protein Kinase C Alpha (PRKCA), are enriched in key signaling pathways associated with cancer, glioma, and ErbB signaling, suggesting that miR-3148 may influence disease progression through modulation of these pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in the context of cervical cancer, miR-3148 functions as a tumor suppressor. Its expression is downregulated in cervical cancer cells, and its upregulation leads to the inhibition of cell proliferation and induction of apoptosis. At the molecular level, bromodomain containing 7 (BRD7) enhances miR-3148 transcription, and miR-3148 directly targets the 3’ untranslated region of Wnt3a mRNA, thereby suppressing the Wnt3a/β-catenin signaling pathway. This dual regulatory mechanism underscores the therapeutic potential of miR-3148 in mitigating tumor growth and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yun Deng, Jian Zhao, Daisuke Sakurai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1003336"}], "href": "https://doi.org/10.1371/journal.pgen.1003336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23468661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23468661"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ran Miao, Ying Wang, Jun Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray Analysis and Detection of MicroRNAs Associated with Chronic Thromboembolic Pulmonary Hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2017/8529796"}], "href": "https://doi.org/10.1155/2017/8529796"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28904974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28904974"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Haiyan Wang, Yun Xie "}, {"type": "b", "children": [{"type": "t", "text": "BRD7-Mediated miR-3148 Inhibits Progression of Cervical Cancer by Targeting Wnt3a/β-Catenin Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-019-00091-8"}], "href": "https://doi.org/10.1007/s43032-019-00091-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32046432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32046432"}]}]}]}