{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that plasma microRNAs can serve as novel biomarkers for acute coronary syndrome (ACS). One investigation evaluated various circulating miRNAs, including MIR3149, to assess their utility in diagnosing ACS conditions such as acute myocardial infarction and unstable angina. These findings highlight the potential diagnostic role of MIR3149 in clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther research has shown that circulating levels of MIR3149, among several other miRNAs, are significantly elevated during the early stage of ACS. This early upregulation suggests that MIR3149 may not only indicate ongoing myocardial injury but also serve as an early warning biomarker to facilitate timely intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these studies propose that MIR3149 plays a dual role in the context of ACS by offering insights into both its potential as a reliable early diagnostic marker and its possible contribution to the underlying pathological mechanisms. Continued investigation into the origins and functional pathways of MIR3149 may further solidify its clinical relevance in the management of ACS.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiangdong Li, Yuejin Yang, Laiyuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0125430"}], "href": "https://doi.org/10.1371/journal.pone.0125430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25933289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25933289"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiang-Dong Li, Yue-Jin Yang, Lai-Yuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated plasma miRNA-122, -140-3p, -720, -2861, and -3149 during early period of acute coronary syndrome are derived from peripheral blood mononuclear cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0184256"}], "href": "https://doi.org/10.1371/journal.pone.0184256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28961259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28961259"}]}]}]}