MIR3150A Gene

HGNC Family Non-coding RNAs
Name microRNA 3150a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the critical regulatory roles of microRNAs (miRNAs) in diverse pathological states, including musculoskeletal disorders such as intervertebral disc degeneration (IDD), a major contributor to low back pain. Although the involvement of circular RNAs in IDD remains to be fully elucidated, the abstract (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "highlights the significance of miRNAs in maintaining disc homeostasis and hints at a broader regulatory network in which members of the MIR3150 family might be engaged.\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate study focusing on colorectal cancer (CRC), a member of the MIR3150 family—specifically miR-3150b-3p—was shown to function as a potent tumor suppressor. The research demonstrated that miR-3150b-3p is downregulated in CRC cells and, when restored, significantly reduced malignant behaviors by directly targeting the oncogene Golgi phosphoprotein 3 (GOLPH3) and consequently attenuating the JAK2/STAT3 signaling pathway. These findings provide a crucial insight into how MIR3150 family members can modulate oncogenic pathways and impair tumor progression (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, the data suggest that while the precise role of MIR3150A in conditions like IDD remains to be clarified, related molecules from the MIR3150 family demonstrate significant biological activity—ranging from the regulation of disc degeneration processes to the suppression of tumorigenesis in CRC. This emerging evidence positions the MIR3150 family as promising candidates for further investigation as potential therapeutic targets in both degenerative and malignant diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bin Zhang, Wei Guo, Chao Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated MiR-3150a-3p Promotes Lumbar Intervertebral Disc Degeneration by Targeting Aggrecan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000488269"}], "href": "https://doi.org/10.1159/000488269"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29554650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29554650"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weiqing Zhang, Xiaoyan Chen, Junzhi Jia "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3150b-3p inhibits the progression of colorectal cancer cells via targeting GOLPH3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Investig Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jim-2019-001124"}], "href": "https://doi.org/10.1136/jim-2019-001124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31678970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31678970"}]}]}]}
Synonyms MIR-3150A, MIR3150
NCBI Gene ID 100422964
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Download Associations
Predicted Functions View MIR3150A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3150A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3150A's ARCHS4 Predicted Functions.

Functional Associations

MIR3150A has 605 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR3150A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3150A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3150A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3150A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3150A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3150A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3150A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3150A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3150A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3150A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3150A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3150A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.