{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCartilage oligomeric matrix protein (COMP) is a multifunctional extracellular matrix molecule that plays a critical role in musculoskeletal development and homeostasis. In cartilage, tendon and growth plate tissues, COMP is expressed as a marker of differentiated chondrocytes and tendon cells, where it participates in cell–matrix interactions that govern cellular proliferation, differentiation and survival. In tendon cell lines derived from transgenic mice, COMP is co‐expressed with other tendon phenotype–related markers and may contribute to maintaining the mesenchymal stem cell–like properties essential for tendon formation and repair."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its well‐established role in skeletal tissues, COMP functions as an important organizer of the extracellular matrix in soft tissues. It mediates cell attachment in ligaments via interactions with integrins (for example, αVβ3 and CD47) and influences collagen fibril assembly and secretion. Moreover, increased COMP expression has been linked to improved responses to mechanical loading and to the orchestration of bone regenerative processes when combined with pro‐osteogenic factors such as BMP2. Aberrant COMP expression or retention—whether because of mutations that trigger intracellular stress or altered degradation by proteases—can disrupt matrix architecture and contribute to fibrotic and myopathic changes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCOMP also exerts key regulatory functions in the vascular system and other organs. It participates in maintaining vascular homeostasis by directly inhibiting thrombin activity, modulating platelet aggregation and limiting vascular smooth muscle cell calcification. Reduced COMP expression has been associated with vascular aging, increased oxidative stress and a shift of vascular smooth muscle cell metabolism and phenotype, while interaction of COMP with mitochondrial proteins (such as prohibitin 2) helps sustain mitochondrial oxidative phosphorylation. Furthermore, COMP is involved in diverse regulatory circuits that impact atherosclerotic lesion morphology, pericyte recruitment in cranial bone regeneration, and even the modulation of fibrotic signaling via TGF‑β in atrial and pancreatic tissues. Notably, recent studies have also highlighted a role for COMP in pulmonary vascular pathology, where its expression is negatively regulated by nuclear circular RNA mechanisms, thereby influencing hypoxia‐induced ferroptosis in pulmonary arterial smooth muscle cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liz Svensson, Attila Aszódi, Dick Heinegård, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein-deficient mice have normal skeletal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.12.4366-4371.2002"}], "href": "https://doi.org/10.1128/MCB.22.12.4366-4371.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12024046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12024046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "R Salingcarnboriboon, H Yoshitake, K Tsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-4827(03)00107-1"}], "href": "https://doi.org/10.1016/s0014-4827(03"}, {"type": "t", "text": "00107-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12837285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12837285"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chuan-Ju Liu, Wei Kong, Kiril Ilalov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.05-3877fje"}], "href": "https://doi.org/10.1096/fj.05-3877fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16585064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16585064"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ke Xu, Yan Zhang, Kirill Ilalov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608744200"}], "href": "https://doi.org/10.1074/jbc.M608744200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17307734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17307734"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Katarzyna A Piróg-Garcia, Roger S Meadows, Lynette Knowles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddm155"}], "href": "https://doi.org/10.1093/hmg/ddm155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17588960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17588960"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Katrin Blumbach, Anja Niehoff, Mats Paulsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of collagen IX and COMP disrupts epiphyseal cartilage architecture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2007.11.007"}], "href": "https://doi.org/10.1016/j.matbio.2007.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18191556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18191556"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hui Geng, Stefan Carlsen, Kutty Selva Nandakumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar2551"}], "href": "https://doi.org/10.1186/ar2551"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19014566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19014566"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "K Blumbach, Y M Bastiaansen-Jenniskens, J DeGroot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.24979"}], "href": "https://doi.org/10.1002/art.24979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19950300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19950300"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Katarzyna A Piróg, Yoshihisa Katakura, Aleksandr Mironov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0082412"}], "href": "https://doi.org/10.1371/journal.pone.0082412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24312420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24312420"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Alexander Burger, Jasmien Roosenboom, Mohammad Hossain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant COMP shapes growth and development of skull and facial structures in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.1251"}], "href": "https://doi.org/10.1002/mgg3.1251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32347019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32347019"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Matthew J Rock, Paul Holden, William A Horton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-009-0355-3"}], "href": "https://doi.org/10.1007/s11010-009-0355-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20033473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20033473"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "A Sengul, S Mohan, C Kesavan "}, {"type": "b", "children": [{"type": "t", "text": "Bone response to loading in mice with targeted disruption of the cartilage oligomeric matrix protein gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.33549/physiolres.932307"}], "href": "https://doi.org/10.33549/physiolres.932307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23098652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23098652"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hui Geng, Kutty Selva Nandakumar, Li Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Incomplete B cell tolerance to cartilage oligomeric matrix protein in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.38046"}], "href": "https://doi.org/10.1002/art.38046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23754310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23754310"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hyuck Choi, Byung-Chul Jeong, Sung-Woong Hur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Angiopoietin-1 Variant COMP-Ang1 Enhances BMP2-Induced Bone Regeneration with Recruiting Pericytes in Critical Sized Calvarial Defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0140502"}], "href": "https://doi.org/10.1371/journal.pone.0140502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26465321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26465321"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jan-Niklas Schulz, Julian Nüchel, Anja Niehoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COMP-assisted collagen secretion--a novel intracellular function required for fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.180216"}], "href": "https://doi.org/10.1242/jcs.180216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26746240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26746240"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Francoise Coustry, Karen L Posey, Tristan Maerz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant cartilage oligomeric matrix protein (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2017.12.014"}], "href": "https://doi.org/10.1016/j.matbio.2017.12.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29309831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29309831"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Valentina Taglietti, Kaouthar Kefi, Iwona Bronisz-Budzyńska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-022-01355-2"}], "href": "https://doi.org/10.1186/s40478-022-01355-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35468843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35468843"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Andrew R Bond, Anna Hultgårdh-Nilsson, Anki Knutsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein (COMP) in murine brachiocephalic and carotid atherosclerotic lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2014.07.029"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2014.07.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25133350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25133350"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dae Joong Kim, Elena D Christofidou, Douglas R Keene, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E14-05-0996"}], "href": "https://doi.org/10.1091/mbc.E14-05-0996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25995382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25995382"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ying Liang, Yi Fu, Ruomei Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein is a natural inhibitor of thrombin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-01-621292"}], "href": "https://doi.org/10.1182/blood-2015-01-621292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26045608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26045608"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yi Fu, Cheng Gao, Ying Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.115.308021"}], "href": "https://doi.org/10.1161/CIRCRESAHA.115.308021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27151399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27151399"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Meili Wang, Yi Fu, Cheng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.08.004"}], "href": "https://doi.org/10.1016/j.bbrc.2016.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27498005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27498005"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yiting Jia, Meili Wang, Chenfeng Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0703-x"}], "href": "https://doi.org/10.1038/s41419-018-0703-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29867124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29867124"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yang Mu, Dan-Ni Zhou, Na-Na Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.9898"}], "href": "https://doi.org/10.3892/mmr.2019.9898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30720083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30720083"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hang Yu, Norah Alruwaili, Bing Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00080.2018"}], "href": "https://doi.org/10.1152/ajplung.00080.2018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31389735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31389735"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Huizhen Lv, Hui Wang, Meixi Quan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2020.10.003"}], "href": "https://doi.org/10.1016/j.matbio.2020.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33068727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33068727"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hui Wang, Ze Yuan, Bianbian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.121.17972"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.121.17972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34983194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34983194"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "XiaoBi Cai, Mingliang Li, Ying Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-β Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12012-023-09799-1"}], "href": "https://doi.org/10.1007/s12012-023-09799-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37584842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37584842"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yi Wang, Hai-Tao Li, Gang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2024.111135"}], "href": "https://doi.org/10.1016/j.cellsig.2024.111135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38479555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38479555"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Aijing Liu, Yingqi Wang, Shuang Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endonuclear Circ-calm4 regulates ferroptosis via a circR-Loop of the COMP gene in pulmonary artery smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2024.176944"}], "href": "https://doi.org/10.1016/j.ejphar.2024.176944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39187041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39187041"}]}]}]}