MIR3156-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 3156-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, the long non‐coding RNA TPT1-AS1 was found to be significantly downregulated and acts as a tumor suppressor by sequestering MIR3156-1 (miR-3156-5p), thereby preventing it from repressing the proapoptotic gene CASP2. This sponging effect ultimately leads to increased CASP2 expression, enhancing apoptotic pathways, reducing cell proliferation, and sensitizing cancer cells to chemotherapy agents such as paclitaxel. In essence, MIR3156-1 normally functions to target CASP2, supporting cell survival and proliferation; however, when it is effectively sequestered by TPT1-AS1, the de-repression of CASP2 contributes to improved therapeutic response and a less aggressive cancer phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Huang, Yabing Zheng, Xiying Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-021-00541-z"}], "href": "https://doi.org/10.1007/s13577-021-00541-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33999360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33999360"}]}]}]}
Synonyms MIR-3156-1
NCBI Gene ID 100422988
API
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Predicted Functions View MIR3156-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3156-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3156-1's ARCHS4 Predicted Functions.

Functional Associations

MIR3156-1 has 164 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 6 datasets.

Click the + buttons to view associations for MIR3156-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3156-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3156-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3156-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3156-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3156-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3156-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.