MIR3156-3 Gene

HGNC Family Non-coding RNAs
Name microRNA 3156-3
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the broad roles of specific microRNAs in cancer pathogenesis. One investigation into cervical cancer emphasized that high‐risk human papillomavirus, through its E6 and E7 oncoproteins, can modulate the expression profile of various cellular microRNAs, thereby contributing to disease development and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the study did not focus on any one microRNA in particular, it underscored the potential importance of aberrantly expressed miRNAs as mediators of oncogenic pathways.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a complementary study in breast cancer, a regulatory network involving the long non‐coding RNA TPT1-AS1 was uncovered. TPT1-AS1 was found to act as a sponge for miR-3156 (referred to in the study as miR-3156-5p), sequestering it away from its target gene CASP2, which encodes a proapoptotic caspase. This interaction was shown to relieve the miRNA-mediated suppression of CASP2, thereby upregulating this apoptotic effector and leading to reduced cell proliferation as well as enhanced sensitivity to paclitaxel treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings suggest that miR-3156 serves as a negative regulator of apoptosis through direct targeting of CASP2; its activity is modulated by TPT1-AS1, highlighting its potential as a biomarker and therapeutic target in breast cancer.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-Fang Xia, Gui-Hua Pei, Ning Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virol J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12985-017-0695-7"}], "href": "https://doi.org/10.1186/s12985-017-0695-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28160779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28160779"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuan Huang, Yabing Zheng, Xiying Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-021-00541-z"}], "href": "https://doi.org/10.1007/s13577-021-00541-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33999360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33999360"}]}]}]}
Synonyms MIR-3156-3
NCBI Gene ID 100423018
API
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Predicted Functions View MIR3156-3's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3156-3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3156-3's ARCHS4 Predicted Functions.

Functional Associations

MIR3156-3 has 169 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.

Click the + buttons to view associations for MIR3156-3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3156-3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3156-3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3156-3 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3156-3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3156-3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3156-3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3156-3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.