{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-3157-3p, encapsulated in NSCLC‐derived exosomes, plays a crucial role in promoting metastasis by enabling communication between tumor cells and the vascular endothelium. This microRNA is significantly upregulated in the circulating exosomes of metastatic NSCLC patients, suggesting its involvement in the pre‐metastatic niche formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOnce transferred to vascular endothelial cells, miR-3157-3p directly targets key regulators such as TIMP and KLF2. This targeting modulates the expression of pro-angiogenic and matrix-remodeling factors including VEGF, MMP2, and MMP9, while also downregulating occludin, a critical tight junction protein. The resulting molecular changes promote angiogenesis and increase vascular permeability, thereby creating a favorable environment for tumor cell extravasation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, the elevated exosomal levels of miR-3157-3p in metastatic NSCLC patients underscore its potential as a blood-based biomarker for early detection of metastasis. Moreover, its mechanistic involvement in endothelial remodeling and niche formation illuminates novel therapeutic avenues aimed at intercepting the metastatic cascade in non-small cell lung carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zijian Ma, Ke Wei, Fengming Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04037-4"}], "href": "https://doi.org/10.1038/s41419-021-04037-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34497265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34497265"}]}]}]}