{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA MIR3161 functions in post‐transcriptional regulation by binding to complementary regions in the 3′ untranslated regions (3′UTRs) of target mRNAs, thereby influencing mRNA stability and translation. In the context of cardiovascular disease, such regulatory activity is critical because polymorphisms in the 3′UTR—such as the rs2953 variant in the CTNNB1 gene—may affect miRNA binding sites. Although the study primarily focused on the association of this polymorphism with the risk of ischemic stroke and coronary artery disease, the potential disruption of binding sites could include those for MIR3161, suggesting a modulatory role in CTNNB1 expression and downstream vascular pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe alteration in miRNA binding dynamics due to such polymorphisms may result in dysregulation of gene expression, contributing to the complex pathogenesis of cardiovascular diseases. Thus, while the study did not directly assay MIR3161, it provides a conceptual framework in which MIR3161 and other miRNAs might influence disease risk by affecting gene regulatory mechanisms at the 3′UTR level."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin-Yi Zhao, Shu-Yan Hu, Jia-Lei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 3' Untranslated Region Polymorphism of CTNNB1 (Rs2953) Alters MiR-3161 Binding and Affects the Risk of Ischemic Stroke and Coronary Artery Disease in Chinese Han Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Neurol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000514543"}], "href": "https://doi.org/10.1159/000514543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33789307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33789307"}]}]}]}