{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‑3163 has emerged as a key post‑transcriptional regulator in cancer by directly binding to specific target mRNAs. In non‑small cell lung cancer, miR‑3163 targets the 3′‑UTR of Skp2 mRNA, thereby inhibiting its translation and leading to reduced Skp2 protein levels with a subsequent increase in the cell cycle inhibitor p27. This effect is further enhanced by the long non‑coding RNA Meg3, which appears to coordinate with miR‑3163 to suppress Skp2 expression and inhibit tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, miR‑3163 contributes to tumor suppression by targeting ADAM‑17, a metalloprotease that activates the Notch signaling pathway; its inhibition results in enhanced sensitivity of cancer cells to targeted agents like sorafenib. In pancreatic cancer, the lncRNA DGCR5 sequesters miR‑3163, resulting in the upregulation of DNA topoisomerase 2‑α (TOP2A) and activation of the Wnt/β‑catenin pathway, whereas restoring miR‑3163 activity suppresses these oncogenic signals and improves chemotherapeutic response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in cervical cancer and nasopharyngeal carcinoma, miR‑3163 plays a crucial tumor‑suppressive role. In cervical cancer, diminished miR‑3163 expression correlates with increased levels of LASP1 and is associated with poor clinical outcomes, a situation exacerbated by the aberrant sponging activity of lncRNA CBR3‑AS1. Similarly, in nasopharyngeal carcinoma, miR‑3163 is competitively inhibited by lncRNA CRNDE, leading to elevated expression of the pro‑metastatic transcription factor TWIST1 and enhanced tumor progression. Together, these studies highlight the multifaceted function of miR‑3163 in modulating oncogenic pathways across diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Su, Dongrui Han, Jingwen Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4151-2"}], "href": "https://doi.org/10.1007/s13277-015-4151-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26482610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26482610"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bin Yang, Chunping Wang, Hui Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2023-1"}], "href": "https://doi.org/10.1038/s41419-019-2023-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31611551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31611551"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shi-Lei Liu, Chen Cai, Zi-Yi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.55636"}], "href": "https://doi.org/10.7150/ijbs.55636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33613108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33613108"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yipin Cai, Yu Huang, Jie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2022_220730N784"}], "href": "https://doi.org/10.4149/neo_2022_220730N784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36591804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36591804"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yiyuan Sun, Liuqing Zhang, Qingwei Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA CRNDE Functions as an Oncogene to Facilitate Aggressive Behaviors of Nasopharyngeal Carcinoma Cells by Modulating miR-3163/TWIST1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-021-00425-5"}], "href": "https://doi.org/10.1007/s12033-021-00425-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34796452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34796452"}]}]}]}