{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that microRNA‐3168 (miR-3168) functions as a potent oncogenic regulator in hepatocellular carcinoma (HCC). Elevated levels of miR-3168 have been observed in HCC tissues, where its expression correlates with poor patient prognosis. Functional assays demonstrate that miR-3168 enhances HCC cell proliferation, promotes liver cancer stem cell self-renewal, and increases tumorigenicity. Mechanistically, miR-3168 directly targets the 3′ untranslated region of p53 mRNA, thereby downregulating this crucial tumor suppressor and impairing its role in cell cycle regulation and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRescue experiments show that knockdown of p53 reverses the differences in cell proliferation, self-renewal, and tumorigenic potential between miR-3168-deficient and control HCC cells, underscoring the centrality of the miR-3168–p53 axis in cancer progression. Additionally, higher miR-3168 expression is associated with resistance to cisplatin-based therapy, suggesting that miR-3168 not only drives malignant behavior but may also serve as a valuable biomarker for predicting chemoresistance in HCC patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tingting Lu, Tao Han, Mingfang Zhao "}, {"type": "b", "children": [{"type": "t", "text": "miR-3168 promotes hepatocellular carcinoma progression via downregulating p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgac062"}], "href": "https://doi.org/10.1093/carcin/bgac062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35926447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35926447"}]}]}]}