MIR3173 Gene

HGNC Family Non-coding RNAs
Name microRNA 3173
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCUEDC2 is a multifunctional protein whose level and activity have been implicated in a range of biological processes including inflammation, tumorigenesis, cardiac injury, and bone formation. Studies have shown that altered CUEDC2 expression in macrophages can lead to excessive proinflammatory cytokine production and an increased risk of colitis‐associated cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while its high expression in various tumors further implicates this protein in inflammatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, CUEDC2 has been linked to cardiomyocyte death under oxidative stress"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and plays a regulatory role in osteoblast differentiation and bone regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWithin this complex regulatory network, microRNAs have emerged as critical modulators. Notably, miR-3173 has been identified as a negative regulator in B-cell acute lymphoblastic leukemia. It functions by directly binding to the 3′ untranslated region of PTK2, thereby suppressing its protein expression. This inhibition leads to reduced cell proliferation, migration, and invasion, highlighting a tumor-suppressive role for miR-3173 and its potential as a therapeutic target in B-ALL."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to the direct actions of miR-3173, other noncoding regulatory mechanisms—such as the lnc-AROD–miR-324-5p axis that modulates CUEDC2 expression—underscore the intricate post-transcriptional control of innate immune responses and viral pathogenicity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these observations not only highlight diverse functions of CUEDC2 in health and disease but also position miR-3173 as a key player in the regulation of oncogenic signaling pathways, offering promising avenues for future therapeutic interventions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Chen, Shao-Xin Wang, Rui Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.05.007"}], "href": "https://doi.org/10.1016/j.celrep.2014.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24882011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24882011"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shaoxin Wang, Jiang Pu, Na Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CUEDC2 Protects Against Experimental Colitis and Suppresses Excessive Proliferation of Intestinal Mucosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-015-3800-z"}], "href": "https://doi.org/10.1007/s10620-015-3800-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26182901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26182901"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhao Jian, Bing Liang, Xin Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201506010"}], "href": "https://doi.org/10.15252/emmm.201506010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27286733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27286733"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jung-Woo Kim, Sin-Hye Oh, Mi Nam Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2562-5"}], "href": "https://doi.org/10.1038/s41419-020-2562-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32393737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32393737"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lijun Tian, Junhua Cao, Qiang Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The downregulation of miR-3173 in B-cell acute lymphoblastic leukaemia promotes cell invasion via PTK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.10.013"}], "href": "https://doi.org/10.1016/j.bbrc.2017.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29066351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29066351"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zixiao Zhang, Tianqi Yu, Haimin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microbiol Spectr (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/spectrum.04206-22"}], "href": "https://doi.org/10.1128/spectrum.04206-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37036350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37036350"}]}]}]}
Synonyms MIR-3173
NCBI Gene ID 100422981
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Download Associations
Predicted Functions View MIR3173's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3173's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3173's ARCHS4 Predicted Functions.

Functional Associations

MIR3173 has 253 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR3173 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3173 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3173 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3173 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3173 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3173 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3173 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3173 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3173 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3173 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3173 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3173 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.