MIR3175 Gene

HGNC Family Non-coding RNAs
Name microRNA 3175
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-3175 functions in a context‐dependent manner across different tissues and disease models. In glioma, for instance, miR-3175 directly targets tumor suppressors such as HOXB1, where its aberrant expression contributes to enhanced cell proliferation and invasion while inhibiting apoptosis, collectively promoting glioma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in human osteoblasts, miR-3175 exerts a cytoprotective role by binding to the mRNA of DCAF1; this interaction leads to reduced degradation of the transcription factor Nrf2, thereby activating antioxidant responses that mitigate dexamethasone-induced oxidative injury and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in ocular surface disease, upregulated miR-3175 promotes epithelial–mesenchymal transition (EMT) in conjunctival epithelial cells by directly targeting Smad7, resulting in increased cell proliferation, migration, and invasion which contribute to pterygium pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in prostate cancer, elevated levels of miR-3175 have been linked to enhanced tumor cell growth and invasion, likely through the suppression of targets such as the cardiac sodium channel β4-subunit gene (SCN4B), underscoring its oncogenic potential in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liang Han, Dehua Liu, Zhaohui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0142387"}], "href": "https://doi.org/10.1371/journal.pone.0142387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26565624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26565624"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aiqin Qi, Juan Han, Fengxia Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3175 and miR-134 affect proliferation, invasion and apoptosis of glioma cells through PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31983121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31983121"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jing Chen, Jin-Qian Liang, Yun-Fang Zhen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04300-8"}], "href": "https://doi.org/10.1038/s41419-021-04300-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34716304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34716304"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xincao Zhong, Jinlong Tang, Hongyi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3175 promotes epithelial-mesenchymal transition by targeting Smad7 in human conjunctiva and pterygium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13698"}], "href": "https://doi.org/10.1002/1873-3468.13698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31774554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31774554"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "He Huang, Xiao-Yan Qing, Qiong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of microRNA-3175 represses cell proliferation and invasion in prostate cancer by targeting the potential tumor-suppressor SCN4B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12292"}], "href": "https://doi.org/10.1002/kjm2.12292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32833340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32833340"}]}]}]}
Synonyms MIR-3175
NCBI Gene ID 100422995
API
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Predicted Functions View MIR3175's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3175's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3175's ARCHS4 Predicted Functions.

Functional Associations

MIR3175 has 1,265 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR3175 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3175 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3175 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3175 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3175 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3175 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3175 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3175 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3175 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3175 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR3175 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3175 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3175 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.