{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided focuses on characterizing novel cell‐surface receptors that regulate immune responses in diverse physiological and pathological settings. For instance, investigations into the determinants of viral host tropism demonstrated that receptors such as CD300lf and CD300ld serve as functional entry points for murine norovirus, with their direct engagement being essential for productive infection and subsequent viral progeny production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies have delineated the roles of paired immunoreceptors in fine-tuning inflammatory responses. In particular, the balance between inhibitory and activating receptors—for example, LMIR3 (CLM-1) versus LMIR4 (CLM-5), and the activating LMIR7 (CLM-3)—has been shown to dictate cytokine production, cell activation, and synergistic signaling with toll-like receptors in myeloid cells, mast cells, and monocytes/macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, data concerning receptors primarily expressed on neutrophils, such as MAIR-IV, underscore the critical role these molecules play in mediating proinflammatory cytokine release and overall innate immune activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Notably, although these studies provide a wealth of insight into receptors that control immune cell function in infectious, inflammatory, and tumor contexts, none of them directly address or mention MIR3180-3. Therefore, the specific biological function of MIR3180-3 remains undefined in these publications and its potential involvement in the immune regulatory networks highlighted herein warrants further investigation.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kei Haga, Akira Fujimoto, Reiko Takai-Todaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1605575113"}], "href": "https://doi.org/10.1073/pnas.1605575113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27681626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27681626"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chaoxiong Wang, Xichen Zheng, Jinlan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD300ld on neutrophils is required for tumour-driven immune suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-023-06511-9"}], "href": "https://doi.org/10.1038/s41586-023-06511-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37674079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37674079"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kumi Izawa, Jiro Kitaura, Yoshinori Yamanishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701100200"}], "href": "https://doi.org/10.1074/jbc.M701100200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17438331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17438331"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yutaka Enomoto, Yoshinori Yamanishi, Kumi Izawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.137166"}], "href": "https://doi.org/10.1074/jbc.M110.137166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20817736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20817736"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takako Nakano, Satoko Tahara-Hanaoka, Chigusa Nakahashi, et al. 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