{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR3181 has been identified as an important epigenetic regulator of the neonatal Fc receptor (FcRn) by targeting the FCGRT gene, which encodes the receptor’s alpha-chain. This regulation is critical because FcRn plays a central role in the recycling and distribution of immunoglobulin G (IgG) and albumin throughout the body, thereby influencing both innate and adaptive immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, investigations in the setting of maternal HIV infection have shown that the expression levels of MIR3181 in both placenta and plasma remain comparable between HIV-infected women on effective antiretroviral therapy and their HIV-uninfected counterparts. These findings suggest that, despite the known derangements in antibody transfer associated with HIV, the MIR3181-mediated regulation of FcRn expression is maintained, possibly ensuring the continuity of FcRn functions during pregnancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies highlight MIR3181’s role in fine-tuning FcRn levels, thereby potentially affecting the immune system’s ability to transport and protect vital antibodies. The preserved expression of MIR3181, even in conditions of HIV infection under antiretroviral therapy, underscores its possible utility as a stable regulatory element in FcRn-mediated immunoglobulin dynamics across various physiological and pathological states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel C Ferguson, Javier G Blanco "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharm Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11095-017-2294-0"}], "href": "https://doi.org/10.1007/s11095-017-2294-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29302759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29302759"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Livo F Esemu, Honore Awanakam, Dieudonne Nanfa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profiles of miR3181 and miR199a in plasma and placenta of virally suppressed HIV-1 infected Cameroonian pregnant women at delivery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0268820"}], "href": "https://doi.org/10.1371/journal.pone.0268820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35594307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35594307"}]}]}]}