{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMechanical asphyxia is one of the most challenging causes of death to confirm in forensic investigations due to the often minimal external signs of trauma. In a recent study, miR-3185 was found to be significantly overexpressed in cardiac tissues obtained from mechanical asphyxia cases when compared to tissues from cases of craniocerebral injury, hemorrhagic shock, sudden cardiac death, and poisoning. Importantly, this elevated miR-3185 expression was independent of confounding factors such as postmortem interval, age, or ambient temperature. The study further identified CYP4A11 as a putative target of miR-3185, with decreased CYP4A11 expression observed in mechanical asphyxia cases—suggesting that the miR-3185/CYP4A11 regulatory axis may underlie molecular mechanisms specific to asphyxial death. These findings indicate that miR-3185 could potentially serve as a valuable biomarker in forensic pathology, aiding in the differentiation and confirmation of mechanical asphyxia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liujun Han, Heng Zhang, Yan Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Forensic Sci Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.forsciint.2020.110293"}], "href": "https://doi.org/10.1016/j.forsciint.2020.110293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32320934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32320934"}]}]}]}