MIR3187 Gene

HGNC Family	Non-coding RNAs
Name	microRNA 3187
Description	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCirculating exosomal miR-3187-5p has emerged as a promising noninvasive biomarker for the early diagnosis of non‐small cell lung cancer. Its altered expression in patient serum suggests that it may assist in the detection of NSCLC at stages 0 or I, potentially enabling earlier intervention and improved patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Circulating miR-3187-3p also plays a regulatory role in colorectal cancer, where it is intricately involved in the circCDC6/miR-3187-3p/PRKAA2 axis. In this setting, circCDC6 acts as a tumor suppressor by binding miR-3187-3p, which in turn upregulates PRKAA2 expression. Given that depletion of miR-3187-3p leads to suppressed tumor cell growth and glycolytic metabolism, manipulation of this axis may represent a therapeutic strategy to control colorectal cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi-Jun Zhang, Xing-Guo Song, Li Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating serum exosomal miR-20b-5p and miR-3187-5p as efficient diagnostic biomarkers for early-stage non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Biol Med (Maywood) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1535370220945987"}], "href": "https://doi.org/10.1177/1535370220945987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32741216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32741216"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chunxiang Zhao, Hong Chen, Kai Min "}, {"type": "b", "children": [{"type": "t", "text": "CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-022-09938-3"}], "href": "https://doi.org/10.1007/s10863-022-09938-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35438362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35438362"}]}]}]}
Synonyms	MIR-3187
NCBI Gene ID	100422854
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MIR3187 has 538 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR3187 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MIR3187 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIR3187 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MIR3187 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MIR3187 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MIR3187 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MIR3187 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3187 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MIR3187 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MIR3187 from the GeneSigDB Published Gene Signatures dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of MIR3187 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIR3187 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of MIR3187 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MIR3187 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of MIR3187 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of MIR3187 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with MIR3187 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.